Topic 7A: Genetics Flashcards

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1
Q

Definition: Gene

A

Sequences of bases in a DNA molecule which code for a polypeptide, resulting in a characteristic.

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2
Q

Definition: Allele

A

A different version of the same gene.

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3
Q

Definition: Loci

A

A point in a gene where the same allele can be found in a pair of chromosomes.

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4
Q

Definition: Genotype

A

The actual alleles an organism has.

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5
Q

Definition: Phenotype

A

The characteristics an organism has

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6
Q

Definition: Dominant allele

A

The allele which is always expressed in the phenotype.

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7
Q

Definition: Recessive allele

A

The allele which is only expressed if two copies are present.

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8
Q

Definition: Co-dominant alleles

A

When both alleles are dominant and therefore both expressed.

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9
Q

Definition: Homozygous

A

When an organism carries two copies of the same allele.

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10
Q

Definition: Heterozygous

A

When an organism carries two different alleles for the same gene.

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11
Q

How do you complete a mono-hybrid cross?

A

1) Write out the parents’ genotype.
2) Show the possible gametes each in a circle.
3) Show all of the possible ways the gametes could combine.
4) Write out the phenotypes produced.

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12
Q

Definition: Sex-linked characteristics

A

When alleles are located on a sex chromosome.

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13
Q

Why are males more likely to show recessive characteristics than females?

A

1) If the characteristic is sex-linked, the allele may be found on the X chromosome.
2) Therefore, the male may only have one allele as they only have one X chromosome.
3) Because of this, even if this allele is recessive, it will be expressed.

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14
Q

Definition: Autosome

A

Any chromosome which is not a sex chromosome.

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15
Q

What are the effects of linkage of autosomal genes?

A

1) Unless crossing over splits up genes on the same autosome they are said to be linked - because they aren’t separated during independent segregation in meiosis I.
2) Therefore you won’t get the expected phenotypic ratio in the offspring.

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16
Q

Definition: Epistasis

A
  • When the allele of one gene masks the expression of alleles of another gene.
  • e.g. if you were bald, you cannot have a widow’s peak regardless of whether or not you have the allele for it.
17
Q

What is the effect of epistatic genes?

A

You won’t get the expected phenotypic ratio.

18
Q

Why is the chi-squared test used?

A

To see if results support a theory (null hypothesis).

19
Q

How do you calculate the degrees of freedom?

A

The number of categories minus one.

20
Q

How would you write a chi-squared test conclusion?

A

1) χ² is larger than ‘0.05’.
2) Therefore, there is significant difference between the observed and expected value.
3) This means the null hypothesis should be rejected.
4) Write a conclusion supporting or disregarding hypothesis.