Topic 7: Pharmacogenomics Flashcards
what is pharmacogetics?
the study of how individual gene variants effects the persons response to drugs.
What is pharmacogenomics?
the study of how varients in alarge collection of genes effcects the perons response to drugs.
What is a haplotype
a group of genes that was inherited together from a single parent - not effected by DNA recombination.
What is pharmacokinetics ?
what the body does to the drug for example
absorbtion
distribution
metabolism
eleimination
What are the ways a cell can absorb a drug?
Passive diffustion
falicitated diffustion
active transport
endocytosis
What class of molecules allows the uptake of organic anions?
OATP - organic anion transporting polypeptides - can have gentic variation of course.
What factors can effect drug distribution in the body?
lipophilicity
blood flow
camilaiary permibality
binding of drug to off target molecuels
What is an example of a drug that losses its efficay by a gentic ploymorphism in p450
clopidogrel is an anti thrombotic and is a prodrug so needs to be metabolised into the active drug, by the enzyme CYP2C19 - loss of funtion in this - loss of drug efficacy
What is pharmacodynamics?
what the drug does to the body for example a change in the drug binding target that causes loss of binding - receptor down regulation, or up regulation SNP of the receptor ect.
