Pharmacodynmics

Question 1

what is B-max?

Answer 1

the maximum binding capacity gives us information about receptor number

Question 2

What is Kd?

Answer 2

the dissociation constant or the concntration of drug that gives 50% occupancy

Question 3

What is Kd an index of?

Answer 3

it is the receptrical of affinity low Kd is a higher affinity

Question 4

What is IC50?

Answer 4

the inhibition constant or the coinctration of ligand needed to displace 50 of the prevoously bound ligand - not the same as Kd

Question 5

does binding = functional activity?

Answer 5

no

Question 6

What is efficacy?

Answer 6

the ability of an agonist to cause a response in a cell or tissue.

Question 7

What is intrinsic efficacy?

Answer 7

the ability of an agonist to activate the receptor not the same as efficacy.

Question 8

what term do we use to quantify agonist function?

Answer 8

EC50 - effective concentration that gives 50% of the maximal response.

Question 9

What is potency measured in

Answer 9

EC50

Question 10

What do we see because of spare receptors?

Answer 10

less than 100% binding we can have 100% response

Question 11

why do we see spare receptors?

Answer 11

signal transduction pathway is amplified, and the respose is limited by a post receptor event.

Question 12

Why would we have spare receptors?

Answer 12

allows for functional responses at low-levels of agonist
and the number of receptors can then control potentency.

Question 13

What is a partial agonist?

Answer 13

an agoinist that cannot elceit the full responce of th endogenous agonist, as they have lowerer intrinsic activity