Topic 6 - Acid-Base Management of Gases During Hypothermia Flashcards
NaCl <>
NaCl<>Na+ + Cl-
AH<>
A- + H+
A- (base) AH (acid)
pH= -log[H+]
changes in the dissociation reaction can affect pH of solution
decrease temp produces decrease in ____ which produces decrease in dissociation which produces ____ in conc of all Ionized components.
energy
decrease
____ temp produces decrease in ____which produces decrease in ____ which produces decrease in conc of all Ionized components.
decrease
energy
dissociation
decrease temp produces decrease in energy which produces decrease in dissociation ….?
which produces decrease in conc of all Ionized components.
At 27 C the pH of neutrality is _?
7.0
pH of neutrality
at equilibrium, the pH produced by reaction:
HOH<> H+ + OH-
solubility of CO2 at 37 C =
0.06 mls CO2/100 mls blood/mmHg
solubility of O2 @37 C =
0.003 mls O2/100 mls bld/mmHg
How is CO2 moved from tissue to the lungs? (3)
Dissolved
Bound to hemoglobin
As HCO3-
Haldane Effect
amount of CO2 that is bound to hemoglobin is effected by PO2/ As pO2 goes down the affinity for hemoglobin and CO2 goes up
PP =
content/stability
solubility is ___ proportional to temp
inversely
Temp increases:
Solubility ?
Solubility decreases
How change pH of blood in a closed system? (3)
- change total CO2 (keep temp constant)
- change temp (keep total CO2 content constant)
- change total CO2 content and temperature
How change pH of blood in a closed system
Increase total CO2 by adding CO2: NO change in temp of acid base disassociation equilibriums:
pCO2 will?
pH will ?
pCO2 will Increase
pH will decrease
How change pH of blood in a closed system
Increase temperature: No change in total CO2 content, pCO2 will change due to change in pH:
drive acid-base disassociation equilibrium to?
pH will?
[H+] will?
drive acid-base disassociation equilibrium to the right
pH will decrease
[H+] will increase
How change pH of blood in a closed system
Change total CO2 content:
pCO2 will?
Change temperature
disassociation equilibrium will?
pCO2 will change producing an inverse change in pH
disassociation equilibrium will change causing a corresponding increase or decrease in [H=]
Temperature increases: no change in CO2 content
Gas solubility?
Gas partial pressure?
gas pressure is ___ than the starting gas pressure?
equilibrium of the water dissociation shifts to the ?
pH will ?
Gas solubility decrease
Gas partial pressure increase
gas pressure is higher than the starting gas pressure
equilibrium of the water dissociation shifts to the right
pH will decrease
Temperature correction of sample, warm sample from 25-37C :
pH will be ?
CO2 will be ?
O2 will be?
pH will be lower than expected (.0147 per degree)
CO2 will be higher than expected
O2 will be higher than expected
