Topic 6 - Acid-Base Management of Gases During Hypothermia

Question 1

NaCl <>

Answer 1

NaCl<>Na+ + Cl-

Question 2

AH<>

Answer 2

A- + H+

A- (base) AH (acid)

Question 3

pH= -log[H+]

Answer 3

changes in the dissociation reaction can affect pH of solution

Question 4

decrease temp produces decrease in ____ which produces decrease in dissociation which produces ____ in conc of all Ionized components.

Answer 4

energy

decrease

Question 5

____ temp produces decrease in ____which produces decrease in ____ which produces decrease in conc of all Ionized components.

Answer 5

decrease
energy
dissociation

Question 6

decrease temp produces decrease in energy which produces decrease in dissociation ….?

Answer 6

which produces decrease in conc of all Ionized components.

Question 7

At 27 C the pH of neutrality is _?

Answer 7

7.0

Question 8

pH of neutrality

Answer 8

at equilibrium, the pH produced by reaction:

HOH<> H+ + OH-

Question 9

solubility of CO2 at 37 C =

Answer 9

0.06 mls CO2/100 mls blood/mmHg

Question 10

solubility of O2 @37 C =

Answer 10

0.003 mls O2/100 mls bld/mmHg

Question 11

How is CO2 moved from tissue to the lungs? (3)

Answer 11

Dissolved
Bound to hemoglobin
As HCO3-

Question 12

Haldane Effect

Answer 12

amount of CO2 that is bound to hemoglobin is effected by PO2/ As pO2 goes down the affinity for hemoglobin and CO2 goes up

Question 13

PP =

Answer 13

content/stability

Question 14

solubility is ___ proportional to temp

Answer 14

inversely

Question 15

Temp increases:

Solubility ?

Answer 15

Solubility decreases

Question 16

How change pH of blood in a closed system? (3)

Answer 16

• change total CO2 (keep temp constant)
• change temp (keep total CO2 content constant)
• change total CO2 content and temperature

Question 17

How change pH of blood in a closed system

Increase total CO2 by adding CO2: NO change in temp of acid base disassociation equilibriums:
pCO2 will?
pH will ?

Answer 17

pCO2 will Increase

pH will decrease

Question 18

How change pH of blood in a closed system

Increase temperature: No change in total CO2 content, pCO2 will change due to change in pH:
drive acid-base disassociation equilibrium to?
pH will?
[H+] will?

Answer 18

drive acid-base disassociation equilibrium to the right
pH will decrease
[H+] will increase

Question 19

How change pH of blood in a closed system

Change total CO2 content:
pCO2 will?
Change temperature
disassociation equilibrium will?

Answer 19

pCO2 will change producing an inverse change in pH

disassociation equilibrium will change causing a corresponding increase or decrease in [H=]

Question 20

Temperature increases: no change in CO2 content
Gas solubility?
Gas partial pressure?
gas pressure is ___ than the starting gas pressure?
equilibrium of the water dissociation shifts to the ?
pH will ?

Answer 20

Gas solubility decrease
Gas partial pressure increase
gas pressure is higher than the starting gas pressure
equilibrium of the water dissociation shifts to the right
pH will decrease

Question 21

Temperature correction of sample, warm sample from 25-37C :
pH will be ?
CO2 will be ?
O2 will be?

Answer 21

pH will be lower than expected (.0147 per degree)
CO2 will be higher than expected
O2 will be higher than expected