Coagulation Book - Cardiac Anesthesia ch 19 Flashcards
Major ligand for platelet activation
Fibrinogen
important ligand for platelet adhesion at low shear stress
vWF
important ligand for platelet aggregation at higher shear stress
vWF
Provides post feedback by activating Cofactors V and VIII
Thrombin
Accelerates cross linking of fibrinogen by activating FXIII
Thrombin
Activates Protein C, which provides neg feedback by inactivating FVa and FVIIIa
Thrombin
Inactivates FVa and FVIIIa
Proteins C and S
Inhibits initiation of extrinsic pathway
TF inhibitor
Heparin’s pH status?
strong biologic acid
negatively charged at physiologic pH
Heparin distribution is mainly in the ? (2)
intravascular space and endothelial cells
Heparin eliminated by what?
kidneys of metabolism in reticuloendothelial system
Heparin boluses can decrease what?
SVR
The CPB priming solution should contain Heparin at what concentration?
approx the same conct as patients blood stream at onset of CPB
ex priming vol of 1500ml should contain 5000units heparin
whole blood heparin concentrations sufficient for CPB
3-4 U/mL
Thrombocytopenia is defined as?
platelet count of <100,000/uL