Topic 20: Multiple Sclerosis Flashcards
What is the prevalence of multiple sclerosis around the world?
causes decrease toward the equator
due to: European background, lack of sun exposure
What is the most common age of onset of MS?
ages 15-25
What is the prevalence of pediatric MS?
6% of MS in total
3 to 10% of MS patients onset </= age 18
What is the prevalence of MS based on gender?
3:1, female:male
What is relapsing-remitting progression of MS?
symptoms then back to baseline
or symptoms that decrease but don’t go fully back to baseline
What is secondary progression of MS?
around 70% of the time
no fluctuations, just steady progression?
What is the Expanded Disability Status Scale (EDSS)?
evaluating the motor changes, not cognitive ones
What is the pathology of MS?
many lesions in the white and gray matter
lesions damage the nerve fibers and tracts
location of lesion causes symptoms
What is the relationship between MS and myelination?
demyelination, remyelination, axonal transection
decreased axonal density in MS plaques
What are the causes of MS?
genes
environment: infections (EBV, Mono, could bring things to the surface), smoking, sun exposure, sodium (activates the immune system)
What is the genetic contribution to multiple sclerosis risk?
no Mendelian relationship
genome wide association studies: HLA or MSC
How can EAE be produced in animals?
can be produced by myelin-specific T cells
mice injected with myelin basic protein and complete Frund’s adjuvant develop demyelinating disease (EAE)
the disease is mediated by myelin basic protein-specific T cells
disease can be transmitted by transfer of T cells from affected animal
What is the immunology of EAE?
- inject MBP
- in a pool of naïve T cells there will be a MBP-recognizing cell
- MBP-specific T cells cause antigen presentation
- there is an expansion of MBP-reactive T cells and they enter the CNS
- these cells are reactivated in the CNS, products produce CNS pathology
How is the process of EAE a model of molecular mimicry?
- virus with molecular similarity to myelin protein (e.g. MBP) interacts with a pool of naïve cells that contains virus-recognizing cells and MBP-recognizing cells
- there is antigen presentation of virus to naïve T cells
- this causes expansion of virus specific T cells trying to get rid of viruses, and expansion of cross-relative MBP-specific T cells which cause accidental activation which can cause alkaline reaction
- these cells enter the CNS, recognize MBP, and initiate inflammatory damage
What do naïve CD4 T cell differentiate into?
differentiate into Th1, Th2, Th17, and T regulatory cells
different path based on environment