Lecture 7: Movement Disorders Flashcards
What are the characteristics of hypokinetic movement disorders?
decreased or slow movement
loss of direct pathway in basal ganglia
loss of dopamine
Parkinsonism
What are the characteristics of hyperkinetic movement?
excessive movement
loss of direct pathway
loss of inhibition of thalamus
chorea, dystonia
What is the direct pathway of movement in the basal ganglia?
facilitates movement
fueled by dopamine (Parkinson’s)
What is the indirect pathway of movement in the basal ganglia?
inhibits movement
slows down movement (Huntington’s)
What other systems is the basal ganglia connected to through the caudate?
limbic
visual
oculomotor
motor cortex
frontal cortex
What are some characteristics of Parkinsonism?
bradykinesia
rigidity
rest tremor
What are the causes of Parkinsonism?
degenerative (PD)
drugs (neuroleptics)
vascular
infectious (HIV)
toxins (CO)
tumors
What injury in the basal ganglia causes Parkinson’s?
decreased action of the direct pathway
indirect system is active so it inhibits the thalamus so motor cortex can’t be active
no gas pedal, all break
What is the process of diagnosis of Parkinson’s disease?
remains a clinical diagnosis (stiffness, rest tremor)
investigations (such as CT, MRI) not proven to be useful for diagnosis on evidence based review but rule out other causes
What are the stats of the incidence of Parkinson’s disease?
5-24/10,000 worldwide
incidence of PD rising slowly with aging population
What are the stats of the prevalence of Parkinson’s disease?
57-371/10,000 worldwide (USA/Canada, 300/10,000)
40% of cases undiagnosed at any time
What are the stats of the prevalence of Parkinson’s disease?
mean 62 years
rare before age 30
10% cases before age 50
What are the risk factors of Parkinson’s disease?
genetic factors: more in younger people
environmental toxins: greater risk in rural area (exposure to pesticides, MPTP)
other factors: aging, older we get more dopamine we loose
biggest risk factor is aging
What are the environmental risk factors of Parkinson’s disease?
manganese (or CO2)
MPTP
epidemiologic studies suggest that agricultural chemicals may play a role
What risk factors cause Parkinson’s disease in younger people?
more likely to be caused by genetic factors
What risk factors cause Parkinson’s disease in older people?
combination to genetic predisposure and environmental or other factors
What are neuroprotective factors against Parkinson’s disease?
exercise, coffee, nicotine
What is the pathology of Parkinson’s disease?
deposition of alpha-synuclein in Lewy bodies (becomes misfolded, clumps up, and get deposited in Lewy body)
degeneration of dopaminergic neurons in pars compacta of substantia nigra
degeneration in brainstem of pigmented nuclei, spinal cord, cortex, gut
Parkinson’s is not just limited to dopamine in substantia nigra, gets deposited in other NS areas as well
What does the substantia nigra look like with Parkinson’s disease and without?
without: makes lots of dopamine so lots of melanin
with: no dopamine so no melanin
What is the Braak system of Parkinson’s disease?
Parkinson’s starts in the gut
Stage 1 of PD: dorsal motor, olfactory, start in the nose or gut then moves to the brain to cause depression, anxiety, and sleep problems (dorsal motor, olfactory, then marches UP brainstem)
Stage 2: coeruleus, sub-coeruleus complex (function in sleep, mood)
Stage 3: motor symptoms
Stages 4-6: cortical involvement, dementia, etc.
so, other signs before motor