Topic 2: The cell cycle and cell growth, death and differentiation Flashcards
Unit 1 Aos1
adult stem cells
undifferentiated cells obtained from various sources and capable of differentiating into related cell types; also known as somatic stem cells
anaphase
stage of mitosis during which sister chromatids separate and move to opposite poles of the spindle fibre within a cell
apoptosis
the programmed death of cells that occurs as a normal and controlled part of an organism’s growth or development
apoptosome
a large protein formed during apoptosis; its formation triggers a series of events that leads to apoptosis
apoptotic body
vesicle containing parts of a dying cell
asexual
reproduction that only requires one parent, leading to the production of a clone
binary fission
process of cell multiplication in bacteria and other unicellular organisms in which there is no formation of spindle fibres and no chromosomal condensation
blebs
bulges of the cell membrane created as the cytoskeleton of the cell breaks down; these break off to form apoptotic bodies
cancer
a disease in which cells divide in an uncontrolled manner, forming an abnormal mass of cells called a tumour
caspases
protease enzymes that break down proteins during apoptosis
caspase cascade
a group of proteins that are sequentially activated to bring about apoptosis
cell-based therapies
the use of stem cells in the treatment of human disorders or conditions to repair the mechanisms of disease initiation or progression
cell cycle
the series of events of cell growth and reproduction that results in two daughter cells
cell division
division of a cell into two genetically identical daughter cells
cell elongation
any permanent increase in size of a cell
centrioles
a pair of small cylindrical organelles, used in spindle development in animal cells during cell division
centromere
the position where the chromatids are held together in a chromosome
chromatid
one of two identical threads in a replicated DNA molecule
chromatin
a mass of genetic material composed of DNA and proteins that condense to form chromosomes during eukaryotic cell division
chromosome
a thread-like structure composed of DNA and protein
crypts
tube-like depressions of the mucosa located in the intestine and the site of glandular cells
cytochrome c
a protein that has a role in the formation of ATP in mitochondria; its leakage from the mitochondria leads to apoptosis
cytokinesis
division of the cytoplasm occurring after mitosis
death receptor
receptors on the surface of the cell that, when activated, lead to apoptosis of the cell