topic 2 Flashcards
Neonatal:
less than 30 days
pediatrics
up to 18 yrs
Neonates have immature
myocardium
Neonates utilize _______ for energy
glucose
Immature myocardium prone to
stretch injury
Adult circuits tend to be
one size fits all”
blood volume for < 10 (kg)
85 cc/kg
blood volume for 11-20 kg
80 cc/kg
blood volume for 21-30 kg
75 cc/kg
blood volume for 31-40 kg
70 cc/kg
blood volume for >40 kg
65 cc/kg
A 1100 gram child has how much BV
93.5 mL
Adult circuit characteristics
3/8” arterial line 3/8”, 1⁄2” venous line Large oxygenators Larger priming volume
pediatric circuit cicuits
1/8”, 3/16”, 1⁄4”, 3/8” arterial line 3/16” 1⁄4”, 3/8”, 1⁄2” venous line Small/Med/Large Oxygenators Smaller Priming Volumes
Neonatal Pack
3/16” x 1⁄4”
infant pack
1⁄4” x 1⁄4”
pediatric pack
1⁄4” x 3/8”
small adult pack
3/8” x 3/8”
adult pack
3/8” x 1⁄2”
sequence to determine appropriate pediatric circuit
It is Imperative to ascertain kg weight prior to choosing 1. Determine BSA (kg weight may suffice) 2. Determine maximum flow rate (KG weight based or BSA based) 3.Choose appropriate pump boot 4. Pick arterial cannula 5. Determine arterial line size 6. Pick venous cannula 7. Determine venous line size
*Packs (1/8” x 3/16”, 3/16”x3/16”, 3/16”x1⁄4”, 1⁄4” x 1⁄4”, 1⁄4”x3/8”, 3/8”x3/8”, 3/8”x1⁄2”)
8. Choose oxygenator 9. Choose arterial filter
CPB normothermic flows for 0-3 kg
200 cc/kg
CPB normothermic flows for 3-10 kg
150 cc/kg
CPB normothermic flows for 10-15 kg
125 cc/kg 1
CPB normothermic flows for 15-30 kg
100 cc/kg
CPB normothermic flows for >30kg
75cc/kg
CPB normothermic flows for >55kg
65cc/kg
kg weight x cc/kg/min flow =
max flow 5.3 kg x 150 cc/kg/min = 795 cc/min or 0.795 L/min
Normothermic CPB flows : 1. BSA:
1.8 l/m/m2 up to 2.4 l/m/m2 2.4 l/m/m2 X 2.00 m2 BSA = 4.8 L/m
Normothermic CPB flows .KG:
50-75 cc/kg/min 75 cc/kg/min x 70 kg = 5.25 L/m
SV FOR Rollerpump Callibration Chart: Boot Diameter 3/16
7 CC x 100 rpm =700 ml/monn
SV FORRollerpump Callibration Chart: Boot Diameter 1/4
13 CC x 100 rpm = 1300 ml/min
SV FOR Rollerpump Callibration Chart: Boot Diameter 3/8
27 CC x 100 rpm = 2700 ml/min
SV FOR Rollerpump Callibration Chart: Boot Diameter 1/2
45 CC x 100 rpm =4500 ml/min
Do NOT exceed ______ RPM for max tubing flow
100
reynolds # equals
(velocity of fluid)(density)(diameter)/viscosity
Poiseuille’s law
Flow = (ΔP x πr4)/( Lx V x 8)
pediatric arterial cannula selection aim:
Aim: utilize the smallest cannula w/ the highest flow rate
Do NOT exceed pressure drop > 100 mmHg
Critical velocity is reached when laminar flow becomes turbulent (Reynolds #)
Higher pressures = higher sheer stress = hemolysis = bad
pediatric venous cannula selection aim:
Aim: drain the patient with the smallest cannulas
Be aware if the cannulation is bicaval or single atrial cannula
Pressure drop is in the -30 to -40 range (pressure-flow curve)
Vacuum Assist Venous Drainage (VAVD) may help but at a cost (micro-emboli may be associated with VAVD)
tubing pack selection for single atrial cannula neonatal
3/16,1/4 <800ml/min
tubing pack selection for single atrial cannula infant
1/4,1/4 800-1278 ml/min
tubing pack selection for single atrial cannula peds
1/4,3/8 1278-2898 ml/min
tubing pack selection for single atrial cannula small adult
3/8,3/8 2898-3500 ml/min
tubing pack selection for single atrial cannula adult
3/8,1/2 >3500 ml/min
tubing pack selection for bicaval atrial cannula neonatal
3/16,1/4 < 800 ml/min.
tubing pack selection for bi caval atrial cannula infant
1/4,1/4 800-1566 ml/min
tubing pack selection for bi caval atrial cannula peds
1/4,3/8 1566-3000 ml/min
tubing pack selection for bi caval atrial cannula small adult
3/8,3/8 3000-3500 ml/min
tubing pack selection for bi caval atrial cannula adult
3/8,1/2 > 3500 ml/min
PED ALFs
Terumo AFX02 Medtronic affinity Integral oxygenator filtration
the new integral filter oxgenators _______is currently
changing the landscape
(FX 05)
Pediatric CannulaSelection: Arterial PROCESS
Determinemaxflow: Cannulation may be aortic / femoral / neck Pressure drop should not exceed 100 mmHg Anticipate larger flow needs when warming Anticipateviscositychanges
Pediatric CannulaSelection: venous PROCESS
Determine max flow Cannulation utilizes Bicaval or Single Atrial Pressure drop -30 to -40 mmHg ( MEASURE IT - its gravity! ) Anticipate larger flow needs when warming Anticipate viscosity changes
bicaval cannulation max flow 12/12
846
bicaval cannulation max flow 12/14
1120
bicaval cannulation max flow 12/16
1197
bicaval cannulation max flow 14/14
1287
bicaval cannulation max flow 14/16
1332
bicaval cannulation max flow 16/16
1377
bicaval cannulation max flow 16/18
1512
bicaval cannulation max flow 18/18
1566
venous 3/16” MAXIMUM VENOUS CALCULATED BFR (mLmin) and PRIME VOLUME (mL/ft)
1100,7
venous 1/4” MAXIMUM VENOUS CALCULATED BFR (mLmin) and PRIME VOLUME (mL/ft)
2000,9.65
venous 3/8” MAXIMUM VENOUS CALCULATED BFR (mLmin) and PRIME VOLUME (mL/ft)
6500,21.7
venous 1/2” MAXIMUM VENOUS CALCULATED BFR (mLmin) and PRIME VOLUME (mL/ft)
—–,38.6
capiox infant ALF flow range
< 2500 ml/min
intersect pediatric ALF flow range
2500-3000 ml/min
GISH ALF flow range >3000 ml/min
> 3000 ml/min
pall leuco guard 3 max flow
3000 ml/min
pall leuco guard 6 flow range
3000-6000 ml/min
basic prime constituents adults
Normosol Hetastarch/Albumin Antibiotic NaHCO3 Mannitol Heparin 10 K units
basic prime constituents peds
Normosol25% Albumin Antibiotic Solumedrol NaHCO3 Heparin 100 units Mannitol CaCl PRBC’s
25% albumin purpose
Largemolecule Aids passification of tubing Elevates C.O.P. and serum osmolarity Good osmotic “pull” from tissues (1.3:1) Be careful in recommendations (i.e X-coating calls for wetting with crystalloid 1st)
Cefazolin(Kefzol,Ancef) dosage
25 mg/kg (max dose = 1 g)
Ampicillin dosage
50 mg/kg (max dose = 1 g)
gentamicin dosage
2 mg/kg (max dose = 80 mg)
nafcilliin dosage
25 mg/kg (max dose = 1 g)
vancomycin dosage
0 -15 mg/kg (max dose = 1 g)
Vancomycin is titrated during CPB. All other of the antibiotics listed can be safely administered to the extra-corporeal circuit prior to the intiation of CPB.
solumedrol dosage pump prime
The pump prime may contain 30mg/kg. methylprednisolone (up to 500 mg) on all to patients undergoing procedures requiring CPB.
Pediatric transplant patients receive ______methylprednisolone when the aortic crossclamp is released.
30 mg/kg
The prime should have a bicarbonate concentration of approximately
24 mEq/L.
formula for he amount of NaHCO3 necessary for a given amount of asanguineous volume
x = 0.025V
f PRBC’s are added to the prime, then a sample should be taken, and NaHCO3 administered according to the following formula:
? mEq NaHCO3 = 0.3(kg wt)(BE)
mannitol purpose
Osmoticdieuretic
ElevatesOsmolarityrapidly
Given over a range of medical disciplines
Oxygen radical scavenger
mannitol dosage
0.25g/kgintheprime
An additional 0.25 g/kg is administered on the release of the aortic cross-clamp.
Since mannitol is 25% solution (5.3 kg x .25 = 1.325 g) And that is 5.3 cc
CaCl2 is not
routinely added to the prime.
perfusate level of CaCL2 should be_______ because_______
0.7 - 0.8 mM/L, if necessary. would allow the appropriate level to be present in the cardioplegia solution of a standard 4:1 solution
PRBCS patient kg weight range intravascular BV index <10KG
85 mL/kg
PRBCS patient kg weight range intravascular BV index 10-20 KG
80 mL/kg
PRBCS patient kg weight range intravascular BV index 20-30KG
75 mL/kg
PRBCS patient kg weight range intravascular BV index 30-40 KG
70 mL/kg
PRBCS patient kg weight range intravascular BV index >40KG
65 mL/kg
PRBCS patient kg weight range intravascular BV index For neonates/infants < 5kg
100 ml PRBC’s are added to the prime
to avoid a prolonged period of asanguineous perfusion.
CPB Hct =
(((IVBV x kg x (patient Hct / 100)) / ((IVBV x kg) + mL prime))) x 100
TEG use in PEDS
Sporatic use in Or/Perfusion labs Takes a long time to finalize (takes patience) Looks at the larger spectrum
TEG Viscoelastic test on whole blood – rotates specimen in cuvette
10 seconds
platelet works
Assesses plateletn function and compares functional and non-functional platelets by percentage (%)
More useful due to looks at function, not number
nirs
Near-infrared spectroscopy (NIRS) technology, such as that used in pulse oximetry, has been used and trusted in the world of medicine for decades.
Near-infrared spectroscopy (NIRS) is a spectroscopic method that uses the near-infrared region of the electromagnetic spectrum (from about 800 nm to 2500 nm)
CDI in line analyzer
Standard of care Important in pediatrics pH stat or Alpha stat use
Capiox Rx05 flow range
< 1500 ml. Min
Capiox sx10 flow range
1500-4000 ml./min.
Capiox sx18 flow range
4000-6000 ml./min
Dlp wire reinforced a ending aortic cannula sizes
8 10 12 16 fr
Biomedicus femoral arterial cannula sizes
8 10 12 14 fr
Max flow dlp 8 fr
750
Max flow dlp 10 fr
1300
Max flow dlp 12 fr
2200
Max flow dlp 14 fr
2900
Max flow dlp 16 fr
4000
Pediatric muf / 4:1cardioplegia
<30 kg
Adult 4:1 cardioplegia
> 30 kg