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2. Top 300 > Top 300 BBW > Flashcards

Top 300 BBW Flashcards

1
Q

Alprazolam BBW

A

Concurrent use with opioids

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2
Q

Amiodarone BBW

A

Arrhythmias, hepatotoxicity, proarrhythmic effects, pulmonary toxicity

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3
Q

Amitriptyline BBW

A

Suicidality; not approved for children <12 y of age

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4
Q

Apixaban BBW

A

Premature discontinuation increases risk of thrombotic events; increased risk of spinal hematoma with spinal puncture or neuraxial anesthesia

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5
Q

Aripiprazole BBW

A

Dementia, suicidality

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6
Q

Atenolol BBW

A

Avoid abrupt withdrawal

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7
Q

Atomoxetine BBW

A

Suicidality in children and adolescents

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8
Q

Azathioprine BBW

A

Malignancy

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9
Q

Baclofen BBW

A

Avoid abrupt discontinuation of oral or intrathecal product

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10
Q

Benazepril BBW

A

Pregnancy, fetal toxicity

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11
Q

Budesonide/Formoterol BBW

A

Asthma deaths; pediatrics, increased risk of hospitalization

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12
Q

Bupropion BBW

A

Suicidality; neuropsychiatric reactions

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13
Q

Canagliflozin BBW

A

Lower limb amputation

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14
Q

Candesartan BBW

A

Pregnancy

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15
Q

Carbamazepine BBW

A

Agranulocytosis, aplastic anemia; dermatological reactions (especially in asians); screen for HLA-B*15:02

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16
Q

Celecoxib BBW

A

GI toxicity, cardiotoxicity, CABG

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17
Q

Ciprofloxacin BBW

A

May exacerbate muscle weakness in patients with myasthenia gravis, tendon inflammation and rupture, peripheral neuropathy, CNS effects, cardiac, dermatologic, and hypersensitivity reactions, aortic dissection and rupture, hypoglycemia, mental health adverse effects

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18
Q

Citalopram BBW

A

Suicidal ideation; not approved for use in children

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19
Q

Clindamycin BBW

A

Colitis

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20
Q

Clobazam BBW

A

Concurrent use with opioids, abuse and addition, dependence and withdrawal reactions

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21
Q

Clonazepam BBW

A

Concurrent use with opioids, abuse, misuse, addiction, dependence, and withdrawal reactions

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22
Q

Clonidine BBW

A

Epidural use

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23
Q

Clopidogrel BBW

A

Reduced CYP2C19 function

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24
Q

Codeine BBW

A

Hepatotoxicity; Children who are CYP2D6 ultrarapid metabolizers; serious risks of misuse, abuse, addiction, overdose, and death; concurrent use with benzodiazepines; immediate release only; serious risk of misuse, accidental ingestion, neonatal opioid withdrawal syndrome

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25
Q

Conjugated Estrogens BBW

A

Breast cancer, cardiovascular disease, endometrial cancer, dementia risks

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26
Q

Dabigatran BBW

A

Use in elderly; risk of stroke at discontinuation; spinal epidural hematoma

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27
Q

Darbepoetin BBW

A

Increased CV, stroke, mortality risk; cancer recurrence

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28
Q

Desvenlafaxine BBW

A

Suicidality; not for use in children; not for bipolar disorder

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29
Q

Dexmethylphenidate BBW

A

Tolerance and dependence

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30
Q

Diazepam BBW

A

Concurrent use with opioids

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31
Q

Diclofenac BBW

A

Cardiovascular, GI risk, CABG

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32
Q

Divalproex BBW

A

Hepatotoxicity, teratogenicity, pancreatitis

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33
Q

Doxepin BBW

A

Suicidality

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34
Q

Dulaglutide BBW

A

Risk of thyroid cancers

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35
Q

Duloxetine BBW

A

Suicidality; not approved for children

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36
Q

Edoxaban BBW

A

Premature discontinuation increases risk of thrombotic events; increased risk of spinal hematoma with spinal puncture or neuraxial anesthesia; reduced efficacy in nonvalvular atrial fibrillation patients with CrCl >95 mL/min

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37
Q

Febuxostat BBW

A

Increased risk of death (cardiac, all-cause)

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38
Q

Fentanyl BBW

A

CYP3A4/5 inhibitors; respiratory depression; transdermal not for use postoperatively; fatalities in children; formulations not interchangeable; fever; care with disposal; REMS program; concurrent use with benzodiazepines or other CNS depressants

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39
Q

Fluoxetine BBW

A

Suicidality; approved in children >7 years of age

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40
Q

Fluticasone/Salmeterol BBW

A

Increased asthma-related deaths

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41
Q

Fosinopril BBW

A

Pregnancy

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42
Q

Furosemide BBW

A

Fluid and electrolyte loss

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43
Q

Hydrocodone BBW

A

Addiction, abuse, misuse, REMS, respiratory depression, accidental ingestion, neonatal opioid withdrawal, alcohol, CYP3A4/5 interactions, hepatotoxicity, concurrent use with benzodiazepines

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44
Q

Ibuprofen BBW

A

Cardiovascular events, GI toxicity, CABG

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45
Q

Indomethacin BBW

A

Cardiovascular events, GI toxicity, CABG

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46
Q

Insulin BBW

A

Risk of acute bronchospasm with inhaled formulation

47
Q

Irbesartan BBW

48
Q

Lamotrigine BBW

A

Serious skin reactions

49
Q

Levofloxacin BBW

A

Myasthenia gravis, tendon inflammation and rupture, peripheral neuropathy, CNS effects, cardiac, dermatologic and hypersensitivity reactions, aortic dissections and ruptures

50
Q

Levothyroxine BBW

A

Not for weight reduction

51
Q

Liraglutide BBW

A

Increased risk of thyroid cancer

52
Q

Lisdexamfetamine BBW

A

Risk of abuse, misuse, diversion

53
Q

Lisinopril BBW

54
Q

Lithium BBW

A

Lithium levels required

55
Q

Lorazepam BBW

A

Concurrent use with opioids

56
Q

Losartan BBW

57
Q

Lurasidone BBW

A

Dementia, suicidality

58
Q

Maraviroc BBW

A

Hepatotoxicity, severe rash, allergic reaction

59
Q

Medroxyprogesterone BBW

A

Cardiovascular, dementia risk, loss of BMD (Depo-Provera); breast cancer

60
Q

Meloxicam BBW

A

Cardiovascular thrombotic events, serious GI bleeding and perforation, CABG

61
Q

Metformin BBW

A

Lactic acidosis

62
Q

Methadone BBW

A

Accidental ingestion; addiction, abuse, and misuse; QTc prolongation; respiratory depression; concurrent use with benzodiazepines; REMS; neonatal opioid withdrawal; conditions for use in opioid addiction; CYP interactions

63
Q

Methotrexate BBW

A

Bone marrow suppression, renal impairment, hepatotoxicity, pneumonitis, GI toxicity, secondary malignancy, tumor lysis syndrome, dermatologic toxicity, opportunistic infections, radiotherapy

64
Q

Methylphenidate BBW

A

Abuse and dependence potential

65
Q

Metoclopramide BBW

A

Tardive dyskinesia

66
Q

Metoprolol BBW

A

Ischemic heart disease with abrupt withdrawal

67
Q

Metronidazole BBW

A

Carcinogenic

68
Q

Mirtazapine BBW

A

Suicidality; not for use in children

69
Q

Morphine BBW

A

Ethanol, addiction, abuse, and misuse, REMS, respiratory depression, neonatal opioid withdrawal, accidental ingestion, concurrent use with benzodiazepines, medication errors

70
Q

Moxifloxacin BBW

A

Myasthenia gravis, tendon inflammation and rupture peripheral neuropathy, aortic dissections, hypoglycemia, delirium

71
Q

Nabumetone BBW

A

Thrombotic events, GI bleeding

72
Q

Naproxen BBW

A

Cardiovascular and GI risk, thrombotic events

73
Q

Nortriptyline BBW

A

Suicidality

74
Q

Olanzapine BBW

A

mortality in elderly patients with dementia-related psychosis; DRESS

75
Q

Olmesartan BBW

76
Q

Oxycodone BBW

A

Addiction, abuse potential; REMS, respiratory depression, accidental ingestion, neonatal withdrawal, CYP3A4/5 interaction, concurrent use with benzodiazepines, medication errors with oral solution

77
Q

Paroxetine BBW

A

Suicidality

78
Q

Phenytoin BBW

A

Hypotension and arrhythmias with IV administration

79
Q

Pioglitazone BBW

A

Heart failure risk

80
Q

Prasugrel BBW

A

Bleeding risk, not recommended in patients >/= 75 years of age, CABG

81
Q

Prenatal vitamin BBW

A

Iron toxicity

82
Q

Prochlorperazine BBW

A

Mortality in elderly with dementia

83
Q

Progesterone BBW

A

Cardiovascular disorders, breast cancer, dementia risk, risk versus benefits

84
Q

Promethazine BBW

A

Children <2 y (fatal respiratory depression)

85
Q

Propranolol BBW

A

Avoid abrupt withdrawal

86
Q

Quetiapine BBW

A

Mortality in elderly with dementia, suicidality, not approved for children <10 y

87
Q

Quinapril BBW

88
Q

Raloxifene BBW

A

Venous thromboembolism, stroke

89
Q

Ramipril BBW

90
Q

Risperidone BBW

A

Mortality in elderly with dementia, DRESS

91
Q

Rivaroxaban BBW

A

Premature discontinuation increases thrombotic risk, risk of spinal/epidural hematoma

92
Q

Rosiglitazone BBW

A

Heart failure, MI risk

93
Q

Sacubitril/Valsartan BBW

94
Q

Sertraline BBW

A

Suicidality, not approved for depression in children, approved for OCD in children >6 y

95
Q

Sofosbuvir BBW

A

HBV reactivation

96
Q

Spironolactone BBW

A

Tumorigenic in animal models

97
Q

Tacrolimus BBW

A

Risk of infection, risk of malignancies, increased mortality in female transplant patients with Astagraf XL, Astagraf XL not approved for liver transplant

98
Q

Tamoxifen BBW

A

Uterine malignancies, stroke, pulmonary embolism

99
Q

Telmisartan BBW

100
Q

Temazepam BBW

A

Concurrent use with opioids

101
Q

Testosterone BBW

A

Secondary exposure

102
Q

Thyroid BBW

A

Ineffective and potentially toxic when used for weight loss

103
Q

Ticagrelor BBW

A

Bleeding risk, use in CABG surgery, avoid aspirin >100 daily

104
Q

Tolvaptan BBW

A

Initiate treatment in hospital to monitor serum sodium. Too rapid correction (eg, >12 mEq/24hr) can result in seizures, coma, and death; correct sodium gradually.

105
Q

Tramadol BBW

A

Addiction, abuse, misuse, REMS, respiratory depression, accidental ingestions, CYP2D6, neonatal withdrawal syndrome, drug interactions, concurrent benzodiazepines, errors

106
Q

Trazodone BBW

A

Suicidal ideation, not for use in children

107
Q

Triamterene/Hydrochlorothiazide BBW

A

Hyperkalemia

108
Q

Triazolam BBW

A

Concurrent use with opioids

109
Q

Valsartan BBW

110
Q

Venlafaxine BBW

A

Suicidal Ideation

111
Q

Vilazodone BBW

A

Suicidal thinking and suicidal behavior

112
Q

Warfarin BBW

113
Q

Ziprasidone BBW

A

Elderly patients with dementia are at increased risk of death, DRESS

114
Q

Zolpidem BBW

A

Risk of complex sleep behaviors (sleepwalking, sleep driving, etc.)

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