Top 14 Drugs Elimination

Question 1

Hepatic metab

Excreted in urine

Answer 1

Acetaminophen

Question 2

Hepatic metab

Excreted in urine

Answer 2

Amlodipine

Question 3

Hepatic metab

Excreted mostly in urine, some in sweat, saliva & feces

Answer 3

Aspirin

Question 4

Hepatic metab

Excreted mainly in bile

Answer 4

Atorvastatin

Question 5

Renal elimination 50%

Answer 5

Glyburide

Question 6

Eliminated 50-70% unchanged in urine

Answer 6

Hydrochlorothiazide

Question 7

hepatic metabolism via CYP2C19

45-80% renal

Answer 7

Ibuprofen

Question 8

CrCl 20-50, reduce dose by 50%

CrCl 5-19 mL/min, extend interval by 48h

Answer 8

Levofloxacin

Question 9

Renal: CrCl 10 to 30 mL/minute: Initial: 5 mg once daily, CrCl <10 mL/minute: Initial: 2.5 mg once daily

Answer 9

Lisinopril

Question 10

Renal: GFR <30 mL/minute/1.73 m2: Use is not recommended.

Hepatic: Mild to moderate hepatic impairment: Initial: 25 mg once daily

Answer 10

Losartan

Question 11

Renal: contraindicated in eGFR <30; eGFR 30 to 45 may consider 50% dosage reduction

Answer 11

Metformin

Question 12

Liver disease - use slow dose titration

Answer 12

Metoprolol succinate

Question 13

Liver disease - use slow dose titration

Answer 13

Metoprolol tartrate

Question 14

Extensive hepatic metabolism

Renal and fecal elimination

Answer 14

Simvastatin