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Histology > Tooth Development > Flashcards

Tooth Development Flashcards

1
Q
  1. What is the acronym for the stages of the development of teeth?
  2. What does each letter stand for?
A
  1. IBCBAM
  2. Initiation Stage
  3. Bud Stage
  4. Cap Stage
  5. Bell Stage
  6. Apposition Stage
  7. Maturation Stage
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2
Q

Accordign to the physiological stages (vs morphological) In tooth development, the development of dental lamina is part of…

A

Initialization

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3
Q

The bud and cap stage form this part of IPDA

A

Proliferation

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4
Q

The early and late bell stage comprise this part of IPDA

A

Differentiation

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5
Q

Enamel and dentin formation comprise this part of IPDA

A

Apposition

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6
Q

The initiation stage of tooth development occurs when?

A

6th/7th weeks

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7
Q
  1. What tissue lining the the stomodeum develops into the oral mucosa during intitation?
  2. What does that give rise to afterwards during initiation?
A
  1. Ectoderm
  2. Dental Lamina
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8
Q

During initiation, induction of the ectodermal (embryonic skin tissue) tissues is triggered by the adjacent..

A

Ectomesenchyme (outer connective tissue)

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9
Q

The scientific term for tooth development is..

A

Odontogenesis

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10
Q

At the 6th week the stomodeum is lined with ectoderm - the outer portion is..

A

Oral Epithelium

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11
Q

During initiation, ectomesenchyme contains these cells which migrated to the area

A

Neural Crest Cells

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12
Q

What separates the developing oral epithelium and the ectomesenchyme during initiation?

A

The basement membrane

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13
Q

During initiation, the dental lamina grows deep into the…

A

Ectomesenchyme

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14
Q
  1. During initiation, thickening of the epithelium happens where tooth formation will occur, which is where?
  2. There is an interaction between the _____ and _______ that is needed, but the exact mechanism remains unclear
A
  1. On the 1st branchial arch
  2. Oral epithelium and mesenchyme
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15
Q

What are the 3 stages of tooth growth, ARE?

A

Apposition, root formation, eruption

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16
Q
  1. The epithelium is derived from..
  2. Ectomesenchyme is embryonic CT derived from..
  3. As the neural tube forms, some cells separate from the neuro-ectoderm and are called ______, they can migrate and histo-differentiate
A
  1. Ectoderm
  2. Neuro-ectoderm
  3. Neural Crest Cells
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17
Q

Identify the tissue layers in the photo

A
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18
Q
  1. After initiation, this stage takes place
  2. When?
A
  1. Bud Stage
  2. 8th week
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19
Q

What occurs during the bud stage?

A

Proliferation

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20
Q
  1. During the bud stage, these migrate to 10 deciduous tooth sites along the future upper and lower jaw
  2. What effect do they have?
A
  1. Neural crest cells
  2. They induce the overlying epithelium, or ectoderm, to become a tooth forming organ, the tooth bud
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21
Q

Identify the numbers in the picture

A
  1. Tooth bud
  2. Oral Epithelium
  3. Ectomesenchyme
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22
Q

During this stage, growth of the dental lamina into a bud occurs in that penetrates the growing ectomesenchyme

A

Bud Stage

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23
Q
  1. During this stage of tooth development, enamel organs form into a cap, surrounding mass of dental papilla from the ectomesenchyme and surrounded by mass of dental sac also from the mesenchyme.
  2. Ultimately what is beginning to form, signifying the start of morpho-differentiation?
  3. When does this stage occur?
A
  1. Early Cap Stage
  2. Tooth Germ
  3. 9th week
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24
Q
  1. What stage is this photo?
  2. Identify the numbers
A
  1. Cap Stage
  2. Enamel organ (aka dental organ)
  3. dental papilla
  4. Dental sac (dental follicle)
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25
Q

What important evenet occurs during the cap stage?

A

Histo-differentiation

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26
Q

During histodifferentiation, the cells develop into different tissues, as seen in the photo below. Identify the structures.

A
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27
Q

This stage of development occurs during the 10th week

A

Late cap stage

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28
Q
  1. As seen in the late cap stage (week 10), the enamel organ later develops into the…
  2. The dental papilla produces the…
A
  1. Enamel
  2. Dentin and Pulp
29
Q
  1. During the late cap stage, the basement membrane separates what?
  2. What does it become later?
A
  1. Enamel Organ and Dental Papilla
  2. The DEJ
30
Q

Identify the 3 lines (hard to see) in the photo

A
31
Q

During the late cap stage, the remaining ectomesenchyme around the enamel organ will form what?

A

Dental Sac

32
Q
  1. In this stage, there is differentiation of the enamel organ into a bell with 4 cell types, and the dental papilla into 2 cell types
  2. When does it occur?
A
  1. Early Bell Stage
  2. 11th week
33
Q

The enamel organ differentiates into these 4 cell types during the early bell stage

A
  1. Inner dental epithelium
  2. Outer dental epithelium
  3. Stellate Reticulum
  4. Stratum Intermedium
34
Q

The dental papilla differentiates into 2 cell types during the early bell stage:

A

Outer cells of the DP, Inner cells of the DP

35
Q

Of the 4 differentiated cell types from the enamel organ in the early bell stage, the inner dental epithelium will form future _______

A

Ameloblasts

36
Q
  1. Of the 2 differentiated cell types from the dental papilla during the early bell stage, the outer cells of the DP will form the…
  2. The central cells will form the…
A
  1. Odontoblasts
  2. Pulp
37
Q

During the bell stage, this is the pattern of enamel knot that extends between the inner and outer dental epithelium

A

Enamel Cord

38
Q
  1. During this stage, morphodifferentiation and early crown formation occurs
  2. When does it occur?
A
  1. Late Bell Stage
  2. 12th week
39
Q

During the late crown stage, what two cell types emerge during morpho differentiation?

A
  1. Odontoblasts
  2. Ameloblasts
40
Q
  1. These are the cells that form dentin
  2. These are the cells that form enamel
A
  1. Odontoblasts
  2. Ameloblasts
41
Q

In addition to the formation of odontoblasts and ameloblasts, what other important formation occurs during the late bell stage?

A

Formation of the Permanent Dentition

42
Q

During the late bell stage, increased proliferative activity leads to formation of another tooth bud on which side of the deciduous tooth germ, forming permanent dentition?

A

Lingual Side

43
Q

Will the bud of the permanent dentition be active or dormant after it’s formed during the late bell stage?

A

Dormant

44
Q
  1. During this stage of tooth development, dental tissues are secreted as matrix in successive layers
  2. Is it the same for every tooth
A
  1. Appositional stage
  2. No
45
Q

Deposition of dental hard tissues is called…

A

Apposition (hence, appositon stage)

46
Q

These three tooth layers are initially secreted as matrix during the apposition stage and partially calcified - serving as a framework for later calcification

A

Enamel, dentin, cementum

47
Q
  1. This is the acronym for the stages of apposition
  2. What do they each mean?
A
  1. EDDE
  2. Elongation of inner enamel epithelium
  3. Differentiation of odontoblasts
  4. Dentin Formation
  5. Enamel formation
48
Q

In the formation of enamel during apposition, a close relationship between enamel and the _____ is necessary for continued enamel to form

A

Stellate Reticulum

49
Q

Ameloblasts and odontoblasts are what category of cells?

A

Tall, columnar cells with long processes

50
Q

When forming enamel and dentin, ameloblasts and odontoblasts leave long processes forming channels in the materials when retreating. Wahat are they called?

A

Dentinal and enamel tubules (note: they are fractional planes where injury is likely to occur from trauma

51
Q
  1. In dentinogenesis, dentin is formed by odontoblasts located in the…
  2. Differentiation of dentin is mediated by growth factors located where?
  3. This substance is laid first, and forms dentin following mineralization
A
  1. Dental Papilla
  2. Inner enamel epithelium
  3. Pre-dentin
52
Q

While forming predentin, odontoblasts move to the center of the dental papilla, leaving behind cytoplasmic extensions surrounded by mineralized dentin, forming

A

Dentinal Tubules

53
Q

Odontoblasts with cytoplasmic processes in dentinal tubules do 2 things

A
  1. Formation of collagen matrix
  2. Deoposition of calcium and phosphate (hydroxyapatite) crystals in the matrix
54
Q

Name the 3 stages of amelogenesis

A
  1. Induction/Differentiation
  2. Secretion
  3. Maturation
55
Q
  1. During the induction stage of amelogenesis, ____________ differentiates into ameloblasts
  2. This occurs upon induction by what?
A
  1. Inner Enamel Epithelium
  2. Pre-dentin and the DEJ
56
Q
  1. During the secretion stage of amelogenesis, ameloblasts form ___________ to secrete matrix
  2. The main secreted protein is..
A
  1. Tomes’ Processes
  2. Amelogenin
57
Q

During the maturation stage of amelogenesis, ameloblasts absorb _____ and organics but secrete _________ to achieve mineralization

A

Absorb water and organics, secrete mineral

58
Q

After (or the last stage of maturation) maturation, the enamel organ fuses to form ________, which remains until the tooth erupts to protect the newly formed enamel

A

Reduced Enamel Epithelium

59
Q
  1. During this stage of tooth development, dental tissues fully mineralize to their mature levels. It varies per tooth.
  2. It is characterized by the completion of what process?
A
  1. Maturation
  2. Calcification
60
Q

Is the maturation of dentin and enamel continuous or incremental?

A
61
Q
  1. During the formation of roots, this is an apical extension of the cervical loop. It provides the framework for root formation
  2. What is it composed of?
A
  1. Hertwig epithelial root sheat
  2. Inner and outer enamel epithelium (not making enamel)
62
Q

Label the arrows in the diagram

A
63
Q
  1. When ectomesenchymal cells from the dental sac come into contact with the newly formed dentin of the root, what do they differentiate into to become?
  2. What do they form?
A
  1. Cementoblast
  2. Cementum
64
Q
  1. In the formation of roots, cementoblasts form..
  2. Fibroblasts form…
  3. Osteoblasts form…
  4. Odontoblasts form…
A
  1. Cementum
  2. Periodontal ligament
  3. Alveolar Bone
  4. Root dentin
65
Q

Does the root grow in the same direction as eruption?

A

No.

66
Q
  1. These are small clusters of cells in the PDL near the cementum
  2. They are cellular residues of the embryonic structure known as….
A
  1. Epithelial Cell Rests of Malassez
  2. Hertwig’s Epithelial Root Sheath
67
Q
  1. This is the supporting structure which develops into fibroblasts to form the PDL
  2. It also develops into osteoblasts to form…
A
  1. Dental Follicle
  2. Alveolar Bone
68
Q
  1. Root dentin is made by
  2. This disintegrates
  3. These migrate into root dentin through the above disintegrated structure
  4. Those migrated structures above then differentiate into these two things
  5. They then form…
A
  1. Osteoblasts
  2. HERS
  3. Dental sac cells
  4. Cementoblasts and Fibroblasts
  5. Cementum and PDL
69
Q

These are PDL fibers embedded in cementum

A

Sharpey’s fibers

Histology (4 decks)

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