Toll- Like Receptors

Question 1

Toll is a protein found in

Answer 1

Drosophila (fruit fly)

Question 2

Highest concentration of TLR found on

Answer 2

Monocytes, macrophages, neutrophils

Question 3

TLR Receptors found on Cell Surfaces

Answer 3

TLR: 1, 2, 4, 5, 6

Question 4

TLR Receptors found on Endosomal Compartments

Answer 4

TLR: 3, 7, 8, 9, 10

Question 5

TLR1
Substance recognized:
Target microorganism:

Answer 5

Substance recognized: Lipopeptides
Target microorganism: mycobacteria

Question 6

TLR2
Substance recognized:
Target microorganism:

Answer 6

Substance recognized: Peptidoglycan, lipoproteins, zymosan
Target microorganism: Gram (+) bacteria, mycobacteria, yeasts

Question 7

TLR4
Substance recognized:
Target microorganism:

Answer 7

Substance recognized: Lipopolysaccharide, fusion proteins, manna
Target microorganism: Gram (-) bacteria, RSV fungi

Question 8

TLR5
Substance recognized:
Target microorganism:

Answer 8

Substance recognized: Flagellin
Target microorganism: Bacteria with flagellae

Question 9

TLR6
Substance recognized:
Target microorganism:

Answer 9

Substance recognized: Lipopeptides, lipoteichoic acid, zymosan
Target microorganism: Mycobacteria, gram (+) bacteria, yeasts

Question 10

TLR3
Substance recognized:

Answer 10

Substance recognized: Double-stranded RNA

Question 11

TLR7
Substance recognized: Single-stranded RNA

Answer 11

RNA viruses

Question 12

TLR8
Substance recognized:

Answer 12

Substance recognized: Single-stranded RNA

Question 13

TLR9
Substance recognized:

Answer 13

Substance recognized: Double-stranded DNA