Tolerance and autoimmunity

Question 1

What type of t cells can emilinate threats in the periphery?

Answer 1

T-regulatory cells

Question 2

How is tolerance achieved?

Answer 2

Non-conforming B and T cells are eliminated via apoptosis before maturity

Question 3

What kind of reactions can autoimmune diseases cause?

Answer 3

Antibody mediated
Immune-complex mediated
T-cell responses

Question 4

How can autoimmune diseases be classified?

Answer 4

Organ specific or systemic

Question 5

What are the risk factors for autoimmune diseases?

Answer 5

Environmental and genetic

Question 6

What is HLA?

Answer 6

Human leukocyte antigen - increased numbers of these expressed causes increased chance of autoimmune disease prevalence

Question 7

What is rheumatoid factor?

Answer 7

A protein which indicates higher risk of aggressive RA

Question 8

What is ACPA?

Answer 8

anti-cyclic citrullinated peptide

If RA patients test positive for anti-CCP antibodies –> RA prognosis is bad