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Virology > Togaviridae > Flashcards

Togaviridae Flashcards

1
Q

Describe the important alphaviruses that cause disease in animals & humans of Togaviridae.

A
  1. Eastern equine encephalitis virus
  2. western equine encephalitis virus
  3. Highlands J virus
  4. Venezuelan equine encephalitis virus
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2
Q

Describe the equine viral encephalitis caused by alphaviruses.

A

Family Togaviridae
-western equine encephalitis virus (WEEV)
-eastern equine encephalitis virus (EEEV)
-venezuelan equine encephalitis (VEEV)

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3
Q

Describe the eastern equine encephalitis virus (EEEV).

A

-zoonotic
-transmitted by mosquitos
-caused by a member of genus alpha virus
-encephalitis in horse & humans
-enzootic in eastern North America, Caribbean basin, Central America, northern & eastern coast of South America
>in North America = eastern & gulf coast to Texas
—occur in late summer & early fall (heavy rainfall)

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4
Q

Describe the EEEV transmission.

A
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5
Q

Describe the EEEV pathogenesis.

A
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6
Q

Describe EEEV in horses VS humans

A
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7
Q

Describe western equine encephalitis virus (WEEV).

A

*CS same as EEEV

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8
Q

Describe WEEV transmission.

A
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9
Q

Describe the classification of Venezuelan equine encephalitis virus.

A
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10
Q

Describe VEEV enzootic cycle VS epizootic cycle,.

A
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11
Q

Describe the clinical signs of VEEV in horses VS humans.

A
  1. Horse
    -non suppurative encephalomyelitis
  2. Human
    -acute, mild, systemic dz
    -headache, chills, coughing, vomit, diarrhea, fever, myalgia, symptoms of encephalitis
    -preg women = placental damage, fetal encephalitis, abortion/stillbirth, congenital dz
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12
Q

Describe the control & prevention of equine encephalitis in horse & humans.

A
  1. Horse
    -formalin inactivated EEEV & WEEV vacc
    -univalent or bivalent prep in combo w other antigens (tetanus toxoid)
    -tissue culture attenuated vacc for VEEV made w strain TC-83
  2. Human
    -no vacc for EEEV & WEEV & VEEV
    -TC-83 live attenuated vacc in lab worker & military
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Virology (24 decks)

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