Tobacco Cessation

Question 1

Which CYP enzyme does smoking induce?

Answer 1

CYP1A2

Question 2

What are some Nicotine Replacement Therapy (NRT) available?

Answer 2

Nicotine Patch
Nicotine Gum
Nicotine Lozenge

Question 3

At what dose should patients starts Nicotine patch?

Answer 3

If > 10 cigarettes/day : 21 mg patch

If < 10 cigarettes/day : 14 mg patch

Question 4

At what dose should patients starts Nicotine gums and lozenges?

Answer 4

1st cigarettes > 30 minutes upon waking : 2 mg
1st cigarettes ≤ 30 minutes upon waking : 4 mg

Min: 9 pieces/ day
Max: 24 pieces/ day

Question 5

What is the partial neuronal alpha-4 beta-2 nicotinic receptor agonist agent used in smoking cessation?

Answer 5

Varenicline (Chantix)

Question 6

What is the partial dopamine and norepinephrine reuptake antagonist agent used in smoking cessation?

Answer 6

Bupropion (Zyban)

Question 7

Which drug should be started 1 week before stoping smoking?

Answer 7

Varenicline (Chantix)

Bupropion (Zyban)

Question 8

BBW of Chantix and Bupropion

Answer 8

Suicidal thinking and behavior

Seizures

Question 9

What is the max dosing of Zyban?

Answer 9

300 mg/day

Question 10

How long can the Nicotine patch stay on?

Answer 10

24 hours