TNK-Tenecteplase Flashcards
1
Q
EXTEND-IA-TNK
NEJM. 2018
A
Patients with LVO (by CTA) within 4.5 hours, eligible for EVT. (Initially with penumbra on CTP.)
Tenecteplase was noninferior to alteplase in restoring perfusion in the territory of a proximal cerebral-artery occlusion. Overall functional outcome was better with tenecteplase than with alteplase. There was no significant difference in the incidence of cerebral haemorrhage.
TNK has longer t 1/2, 20 mins serum and 100 mins at site, and can be given as single bolus.
Dose unsettled.
