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Biology of Disease > TLRs > Flashcards

TLRs Flashcards

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1
Q

TLR1 (TLR1/2

heterodimer)

A

PAMP - Triacyl lipoproteins (Gram-ves)

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2
Q

TLR2 and TLR2/6
and TLR2/1
heterodimers

A 
PAMP
Peptidoglycan (Gram+ves)
Zymosan (yeast/fungi),
Diacyl lipoproteins, GPI-linked
proteins (Trypanosomes)

DAMP
Heat shock proteins,
HMGB-1, urate
crystals

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3
Q

TLR3

A 
PAMP
ds RNA (virus)

DAMP
mRNA (necrotic cells)

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4
Q

TLR4

A

PAMP
LPS

DAMP
Heat shock proteins,
HMGB-1

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5
Q

TLR5

A

PAMP

Flagellin

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6
Q

TLR6 (TLR2/6

heterodimer)

A

PAMP
Diacyl lipopeptides (Gram+ves)
Zymosan (yeast/fungi)

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7
Q

TLR7

A

PAMP
ssRNA (virus)

DAMP
ssRNA

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8
Q

TLR8

A

PAMP
ssRNA (virus), phagocytosed bacterial
RNA

DAMP
ssRNA, microRNA

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9
Q

TLR9

A

PAMP
unmethylated CpG-DNA (bacterial
DNA)

DAMP
Self-DNA, HMGB-1

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Biology of Disease (4 decks)

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