tissue morphogenesis Flashcards
5 fundamental tissues
epithelium, connective tissue, muscle, nerve and blood
5 characteristics of epithelia
- Avascular adjacent to connective tissue
- Organized on top of ECM
- Have close cell-cell contact
- have specialized junctions
- have strong apico-basal polarity
Why do we care about epithelia?
- Barrier
- Compartmentalize
- Secrete
- Absorb
distinct junctions of epithelial cells (4)
- occluding (AKA tight)
- cell-cell anchoring
- cell-matrix anchoring
- communicating (ie gap junctions)
two functions of tight junctions
selectively control paracellular permeability gate and partition apical from basolateral
most commonly studied transmembrane adhesion protein
cadherins
anchoring junction components (3)
Transmembrane adhesion proteins, linker proteins, and cytoskeletal elements
simple epithelium
single cell layer, all cells bridge from apical to basement membrane
stratified epithelium
multiple epithelial cell layers
pseudostratified epithelium
multilayered based on nuclei, actually single layered
translational epithelium
mix of single and multiple cell layers
what epithelial surface faces lumen or free surface
apical
what epithelial surface interacts through hemidesmosomes with the basement membrane
basal
what cell-cell anchoring junction is connected to actin
adherens junction
what cell-cell anchoring junction is connected to intermediate filaments
desmosomes
