filaments Flashcards
three dynamic filament systems
microfilaments, intermediate filaments and microtubules
some examples of things that cells can do bc they have a dynamic cytoskeleton
crawl, move vesicles, cytokinesis, swim, assemble junctional complexes
function of microfilaments
structural, mechanical, support myosin-based contractility and motility
function of microtubules
long distance transport, mitotic spindle, signaling
function of intermediate filaments
structural, mechaanical
component of microfilaments
actin
component of microtubules
a/b tubulin dimers, g/b dimers
components of intermediate filaments
lamins, keratins, neurofilament proteins
structure of microfilaments
two start right-handed helix, polar
structure of microtubules
11-15 protofilaments form hollow tube, polar
structure of intermediate filaments
coiled-coil dimer assemble into flexbile, non polar polymers
energy source of each type of primary filament system
ATP for microfilaments, GTP for microtubutles, none for intermediate filaments
how does actin affect cell locomotion
actin polymerization drives locomotion of the cell by assembling with the barded, fast growing end, near the plasma membrane at the front end of the cell, helping push membrane fwd
where is actin found
throughout the cells cytoplasm and in a thick cortex just underneath the plasma membrane
dynamic instability
characteristic behavior of microtubules, where the ends of microtubules switch between fast growing and faster shrinkage called catastrophe. Driven by nucleotide state of tubulin dimers near the ends