filaments Flashcards

1
Q

three dynamic filament systems

A

microfilaments, intermediate filaments and microtubules

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2
Q

some examples of things that cells can do bc they have a dynamic cytoskeleton

A

crawl, move vesicles, cytokinesis, swim, assemble junctional complexes

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3
Q

function of microfilaments

A

structural, mechanical, support myosin-based contractility and motility

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4
Q

function of microtubules

A

long distance transport, mitotic spindle, signaling

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5
Q

function of intermediate filaments

A

structural, mechaanical

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6
Q

component of microfilaments

A

actin

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7
Q

component of microtubules

A

a/b tubulin dimers, g/b dimers

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8
Q

components of intermediate filaments

A

lamins, keratins, neurofilament proteins

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9
Q

structure of microfilaments

A

two start right-handed helix, polar

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10
Q

structure of microtubules

A

11-15 protofilaments form hollow tube, polar

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11
Q

structure of intermediate filaments

A

coiled-coil dimer assemble into flexbile, non polar polymers

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12
Q

energy source of each type of primary filament system

A

ATP for microfilaments, GTP for microtubutles, none for intermediate filaments

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13
Q

how does actin affect cell locomotion

A

actin polymerization drives locomotion of the cell by assembling with the barded, fast growing end, near the plasma membrane at the front end of the cell, helping push membrane fwd

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14
Q

where is actin found

A

throughout the cells cytoplasm and in a thick cortex just underneath the plasma membrane

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15
Q

dynamic instability

A

characteristic behavior of microtubules, where the ends of microtubules switch between fast growing and faster shrinkage called catastrophe. Driven by nucleotide state of tubulin dimers near the ends

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