Tissue Healing Flashcards
Connective Tissue section in PPT
Connective tissue
characterized by widely dispersed cells and a large volume of extracellular matrix
ex: bones, bursae, capsule, cartilage, ligaments, tendons, skin
Extracellular matrix
the part of connective tissues outside the cells, It comprises almost the entire volume of the tissue and determines the tissues function
- Fibrous/fibular(collagen fibers & elastin)
- Ground Substance/ interfibrillar
Cellular (extracellular matrix)
-Fibroblasts, fibrocytes
>Basic cell of most connective tissues
>Produce fibers of connective tissues and specialized cells
»_space;Chondroblast, tenoblast etc.
Collagen Fibers (IMPORTANT)
-Responsible for strength, stiffness and resistance to tensile forces
>Tensile strength similar to steel
Elastin (IMPORTANT)
- Flexibility and extensibility
- Found in tissues that need “give”
- Smaller portion of fibrous component
Intended to stretch? Or be stable?
Types 1 Collagen (important)
-90% of all collagen found in tendons, ligaments, joint capsules, synovium, bone
>Strongest type of collagen
Type 2 Collagen (important)
mainly in cartilage and intervertebral discs
Type 3 Collagen (important)
skin, muscle tendon sheaths
Interfibrillar/Ground Substance
Extracellular Matrix
-Fluid component of tissues; water and proteins Serves to: >Reduce friction between fibers >Form links between collagen fibers >Resists compressive forces >Helps dissipate tensile forces
What does the makeup and orientation of the tissue do/allow?
Gives it it’s strength and ability to withstand different forces
Mechanical Behavior of CT
- Dependent on proportions of collagen to elastin and structural orientation
- Collagen 5 times stronger than elastin
Increased collagen =
increased strength and decreased flexibility
Increased elastin =
greater flexibility and decreased strength
Parallel orientation of CT
-Resists tensile forces in that direction
>Tendon
Random orientation of CT
Withstand forces in a variety of directions