tissue environment

Question 1

what is the 3 distinct areas oral mucosa is split into

Answer 1

1) Epithelium
2) Connective Tissue
or lamina propria
3) Sub-mucosa

Question 2

what is the structure of intermediate filaments and where are they

Answer 2

ropelike fibres
dia- 10nm
no polarity

• one group forms nuclear lamina
• other extends across cytoplasm giving mechanical strength
• In epithelial tissue, span the cytoplasm from one cell-cell
  junction to another, strengthening the entire epithelium.

Question 3

only epithelial cells contain keratin

Question 4

describe keratine

Answer 4

type 1 (found in chromosome 17) and type 2 (found in chromosome 12) one is acidic and one is basic, both have introns and exons

Question 5

what is the definition of the connective tissue

Answer 5

any supporting tissue that lies between other tissues and consists of cells embedded in a relatively large amount of extracellular matric - bone, cartilage, loose connective tissue

Question 6

definition of extralcellular matrix

Answer 6

a complex netweork of polysaccharides (such as
glycosaminoglycans or cellulose) and protiens (such as collagen) secreted by cells.

Question 7

what can the extracellular matrix be useful for

Answer 7

serves as a structural element in tissue and also influences their development and physiology

Question 8

what is the function of the extracellular matrix

Answer 8

• Support for cells.
• the pattern regulates polarity, cell division, adhesion and motility
• involved in development (migration and differentiation)
• growth factors

Question 9

describe the extracellular matrix

Answer 9

• Not solely made up of cells
• Intricate network of macromolecules
• Secreted by cells locally
• Assembled and organised into meshwork by cells producing
  them
• Varieties of form: bone, teeth, cornea, tendons
• Not inert scaffold
• Active and complex role in regulating cell behaviour
• Influences: Cell survival, development, migration, proliferation,
  shape and function

Question 10

what are the functions of the endothelial cells

Answer 10

Barrier Function:
1) barrier between blood and rest of the body tissue
2) selectively permeable for certain chemicals and white blood cells to move across from blood to tissue
3) or for waste and carbon-dioxide to move from tissue to blood.

Regulating blood flow:
in hypertension this flow rate is restricted- so
We need something whether it be drugs or changes to lifestyle that reduce this