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Pathology - Principles > Tissue Damage, Inflammation and Repair - Lecture 2 > Flashcards

Tissue Damage, Inflammation and Repair - Lecture 2 Flashcards

1
Q

What are the physical characteristics of inflammation?

A 
Redness (Rubor) 
Heat (Calor) 
Swelling 
Pain (dolor) 
Loss of function
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2
Q

What is Necrosis?

A

Premature death of cells and living tissue

- caused by external factors

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3
Q

What causes Necrosis?

A 
Infections 
Toxins 
Trauma 
Extremes of Temperature 
Radiotherapy
Chemotherapeutic agents
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4
Q

What is Apoptosis?

A

The process of programmed cell death death - requires an energy source

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5
Q

What does Resolution of tissues mean?

A

This means the complete restoration of tissues to normal after an episode of acute inflammation

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6
Q

What is healing by resolution?

A

This is restitution with no/minimal residual defect

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7
Q

What is healing by repair?

A

Residual defect present

- Fibrosis occurs and scar tissue formed

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8
Q

What is Suppuration?

A

This is formation of pus

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9
Q

What is pus composed of?

A 
Living cells 
Dying cells 
Dead Neutrophils 
Cellular debris 
Bacteria
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10
Q

What does accumulation of pus form?

A

An Abscess

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11
Q

What is Organisation of tissues?

A

Replacement of tissue by granulation tissue

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12
Q

What favours the formation of granulation tissue?

A

Lagre amount of fibrin
Substantial Necrosis
Exudate and debris cannot be removed

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13
Q

What are the predominant features in repair?

A

Angiogenesis - new blood cell formation
Fibroblast Proliferation - Connect tissue formation
Collagen Synthesis - Formation of scars

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14
Q

What are the repair processes controlled by?

A

Growth factors

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15
Q

What causes Chronic Inflammation?

A

Persistent acute Inflammation due to on-degradable pathogens

Viral Infection

Persistent foreign bodies

Autoimmune reactions

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16
Q

What are the cells involved in Chronic inflammation?

A 
Monocytes 
Macrophages 
Lymphocytes 
Plasma Cells 
Fibroblasts
17
Q

What are the cells involved in

A 
Neutrophils 
Basophils 
Eosinophils 
Monocytes
Macrophages
18
Q

What is the onset of Acute Inflammation?

A

Immediate

19
Q

What is the onset of Chronic Inflammation?

A

Delayed

Pathology - Principles (5 decks)

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