Tick borne diseases Flashcards
Incubation period of Lyme disease?
3-32 days
What bug causes Lyme disease?
Borrelia burgdorferi
How is borrelia burgdorferi transmitted?
Deer tick
What is stage I of Lyme disease?
Erythema migrans
What is stage II of Lyme disease?
- Days to weeks after erythema migrans
- Spread to lymphatics
- Intermittent flu-like symptoms, HAs, neckaches, myalgias
What are sequelae of stage II Lyme disease?
This is secondary to early disseminated illness • Meningitis • Encephalitis • Cranial neuritis • Peripheral radiculoneuropathy
What is stage III of Lyme disease?
Late, persistent infection
• Arthritis (60% of patients – large joints)
• Chronic CNS disease state (chronic encephalitis, transverse myelitis, axonal neuropathy)
Lyme Disease serological testing?
- Test for IgM 3-6 weeks after infection
- IgG will persist but won’t show chronicity (will cross react with treponema pallidum but WON’T produce a false positive VDRL)
What is treatment for Lyme disease?
21 days of doxycycline
What pathogen causes RMSF?
Rickettsia rickettsii
Where does rickettsia rickettsii multiply?
In vascular endothelium
What is the pathogenesis of RMSF?
Damage to the vascular endothelium leads to activation of complement, microhemorrhages, and microinfarcts
Onset to RMSF symptoms after tick bite?
1 week
What are initial symptoms of RMSF?
- Fever, chills, malaise, N/V, myalgias, photophobia, HA
* Papular rash 4-5 days after onset of fever (starts distally and moves up and hits palms and soles)
What might show on lab work in a RMSF patient?
- Elevated LFTs
- Thrombocytopenia (remember you have activation of clotting cascade) BUT DIC IS RARE!!!
- Hyponatremia (compensatory ADH release)
- Azotemia
