thyroid plus randos

Question 1

HLA associated with hashimoto

Answer 1

HLA-DR5

Question 2

histologic findings of hashimoto thyroiditis

Answer 2

hurthle cells

lymphoid aggregates w/germinal centers

• increased risk for non-hodgkins lymphoma

Question 3

causes of congenital hypothyroidism

presentation and ‘name’ of congenital hypothyroidism

Answer 3

CRETINISM

maternal hypothyroidism
thyroid agenesis

thyroid dysgenesis

pot-belly

pale

puffy face

protruding umbilicus

protuberant tongue

poor brain development

6 p’s!

Question 4

subacute thyroiditis(de quervain) presentation

Answer 4

self-limiting hypothyroidism after a URI

jaw pain

increased ESR

very tender thyroid

think: de querVAIN is associated with PAIN

Question 5

riedel thyroiditis presentation

Answer 5

form of hypothyroidism where thyroid is replaced by fibrous tissue - rock hard

hard painless goiter

can extend to local structures

Question 6

PTH is released from what cell type?

Answer 6

chief cells in the parathyroid

Question 7

hashimoto has an antibody against?

Answer 7

thyroperoxidase

anti-thyroperoxidase can be seen in graves as well but is most common in hashimoto

Question 8

most sensitive test to SCREEN for thyroid disease

Answer 8

serum TSH

most sensitive for SCREENING

Question 9

what is ESR

Answer 9

it is the erythrocyte sedimentation rate

it is a marker of chronic inflammation; in inflammation there stacking of the erythrocytes due to increased “pro-sedimentation” products like fibrinogen. this causes an increase in the ESR