Thyroid Pharm Flashcards
hw is idoide transported into thyroid follice?
3 inhibitors?
ATP Na/I symported
ocidative phosphorylation uncouplers
thiocyanate
perchlorate
function of TPO?
oxidize iodide and organification to tyrosyl residues of thyroglobulin to form MIT and DIT
then couple MIT and DIT to form T3 or 2 DIT to form T4
wt is thyroglobulin? how is it stored?
protein that is used to synthesize T3/4. stored as colloid in the lumen of follicle
wt stumulates thyroglobulin endocystosis?
TSH
how does lithium affect TH?
inhibits thyroid release
hw are T3 and T4 transported in blood?
bound to thyroxine binding globulin
T4 also w transthyretin
is there more T3 or T4 in blood?
which is more potent
T4 more
T3 potent
wt converts T4 to T3?
wr is it most active?
2 forms of enzyme? locations?
effect of propylthiouracil on forms?
5-deiodinase
liver
D1
- liver, kidney, thyroid
- inhib
D2
- brain, etc.
- no effect
hw is TH metabolized?
effect?
P450
inducers inc conversion of T4 to T3
structure of levothyroxine?
oral uses?
hypothyroidism
hashimoto thyroiditis
suppression of TSH thyroid carcinoma
suppresnion of TSH for goiter
iv use for levothyroxone?
myedema coma
3 agents that reduce thyroxine bioavailability?
Ca Carbonate
Aluminum hydroxide
Cholestyramine and colesevelam
agent that inc thuroid binding globulin?
consequence?
estrogen
inc dose if taking OCPs or dec if women stops taking OCPs
agent that inc thuroid binding globulin?
glucocorticoids
2 agents that inhibit 5-deiodinase?
propylthiouracil
amiodarone
