endo pharm

Question 1

tx for anovulatory women?
mech?
2 other uses?

Answer 1

hCG
LH analog
male infertility and cryptorchidism

Question 2

drug that stimulates development of ovarian folliles?
mech?
other use?

Answer 2

Menotropin
FSH and LH analog

promotes male spermatogenesis

Question 3

cause of laron dwarfism?
tx?
AE?

Answer 3

defect in GH receptor

IGF-1 analog

hypoglycemia

Question 4

tx for hypothalamic dwarfism?

Answer 4

somatropin

Question 5

tx for prolactinemia?
mech?
AE?

Answer 5

bromocriptine
carbergline

D2 agonists

hypotension

Question 6

drug to diagnose hypothyroidism?

mech?

Answer 6

Protirelin

TSH analog

Question 7

2 gonadotropin AE in women? 1 men?

Answer 7

ovarian hyperstimulaiton
multiple births

gynecomastia

Question 8

tx for infertility due to PCOS?
mech?

AEs?

Answer 8

Clomiphene

estrogen receptor antagonist –> inc gonadotropin and ovulation

Question 9

MOA of leuprolide?

5 uses?

Answer 9

synthetic GnRH agonist –> down regulate GnRH receptor

endometriosis
uterine fibroids
prostate cancer
breast cancer 
precocious puberty

Question 10

drug to tx breast cancer by binding ER?

mech?

Answer 10

Tamoxifen

anti estrogenic in breast, estrogenic in bone

Question 11

drug to tx osteoporosis?

Answer 11

Raloxifen

Question 12

3 aromatase inhibitors?
use?
caveat?

Answer 12

anastrozole, exemestane, letrozole

postmenopausal breast cancer
+ long GnRH agonist

Question 13

2 androgen receptor antagonists?

caveat

Answer 13

Flutamide, bicalutamide

give w long GnRH agonist

Question 14

mech of finasteride?

use?

Answer 14

5alpha reductase inhibitor

BPH