Thyroid Lymphoma Flashcards

1
Q

Thyroid lymphoma- basic demographics

A

fewer than 5% of malignancies

  • women > men (4:1 ratio)
  • majority are non-Hodgkin’s lymphomas of B-cell origin
  • 50% of lymphomas arise from background of pre-existing Hashimoto’s thyroiditis
  • subgroup of MALT
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2
Q

Clinical presentation thyroid lymphoma

A

rapidly enlarging thyroid mass and compressive symptoms
history of hypothyroidism (remember association with Hashimoto’s)
-few patients have B symptoms
-diagnosis considered in patients with goiter

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3
Q

Work-up of thyroid lymphoma

A

CT neck, chest, abdo with or without PET

-if FNA not diagnostic, then core needle biopsy

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4
Q

Management of thyroid lymphoma

A
diffuse large B cell lymphoma
CHOP chemotherapy followed by radiation for stage IE or IIE disease
C- cyclophosphamide
H- hydroxydanorubocin (Doxorubin)
O- oncovin (Vincristine)
P- prednisone
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5
Q

Role of surgery in thyroid lymphoma

A

surgery generally not required but subset of patients with significant compressive symptoms from big tumours could benefit from palliative total or subtotal thyroidectomy
-can use surgery for diagnostic biopsy when diagnosis cannot be made by FNAB or CNB

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