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ClinLab > Thyroid Function Tests > Flashcards

Thyroid Function Tests Flashcards

1
Q

What are the 4 functions of the thyroid gland?

A
  • control metabolism
  • regulate body temperature
  • influence HR
  • regulate protein production
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2
Q

The thyroid produces what 3 hormones?

A
  • thyroglobulin (Tg)
  • T4
  • T3
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3
Q

Which of the 3 hormones produced by the thyroid is the most active form?

A

T3

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4
Q

Which of the 3 hormones is the most predominant hormone secreted by the thyroid?

A

T4

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5
Q

What substance is essential for the production of T3/T4?

A

iodine

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6
Q

What % of T3 is converted from the T4?

A

80%

*20% converted by thyroid

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7
Q

Describe the hypothalamus-pituitary-thyroid axis (cycle)?

A

Hypothalamus (TRH) > pituitary gland (TSH) > thyroid gland to produce T4+T3

production of T4+T3 down-regulates the hypothalamus + pituitary gland

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8
Q

What is the difference between, primary, secondary or tertiary thyroid disease?

A
  • primary = problem at thyroid
  • secondary = pituitary gland
  • tertiary = hypothalamus
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9
Q

What is the normal range of thyroid-stimulating hormone (TSH)?

How long does it take TSH levels to adjust?

A
  1. 45-4.5 mIU/L

- take 6-8 weeks to adjust

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10
Q

What 3 medications can result in a false decrease of thyroid-stimulating hormone (TSH)?

A
  • Dopamine
  • High dose glucocorticoids
  • Levodopa
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11
Q

What 2 medications can result in a false increase of thyroid-stimulating hormone (TSH)?

A
  • Lithium

- Amiodarone

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12
Q

What is the best test to further evaluate an abnormal TSH?

What is the normal range

A

Free T4 (FT4)

Normal range = 12-30 pmol/L

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13
Q

T4 decreases with the use of what medication?

A

lithium

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14
Q

Free T3 (FT3) is valuable in evaluating patients with what condition?

Free T3 test is not recommended for the diagnosis of what thyroid condition?

A
  • thyrotoxicosis

- hypothyroidism

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15
Q

What is the normal range of Free T3(FT3)?

A
  1. 0-7.0 pmol/L

* may decrease by <25% in older persons

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16
Q

If you have a high suspicion for hypothyroidism what test should you order?

A

TSH

17
Q

If you have a high suspicion for hyperthyroidism what tests should you order?

A

TSH, FT4, FT3

18
Q

Which of the thyroid function tests alone is good enough to monitor levothyroxine therapy?

A

TSH

19
Q

TRH stimulation will increase TSH and thyroid function in what type of hypothyroidism?

A

(central) hypothalamic hypothyroidism

20
Q

What lab findings help in the diagnoses of autoimmune hypothyroidism?

A

-Check for high levels of both:

anti-TPO & Tg antibodies

21
Q

What % of subclinical hypothyroidism will progress to overt hypothyroidism?

A

55%

22
Q

What substance is produced and used by the thyroid to make T3/T4?

A

Thyroglobulin (Tg)

23
Q

What is the best initial screening test for thyroid functioning disorders?

A

TSH

ClinLab (11 decks)

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