Thyroid disorders values

Question 1

TSH level when symptoms of hypothyroidism becomes apparent (called Clinical hypothyroidism or overt hypothyroidism)

Answer 1

TSH >10 mIU/L

Question 2

Daily replacement dose of levothyroxine for those with no residual thyroid function

Answer 2

1.6 ug/kg/d (100-150 ug)

Question 3

Typical levothyroxine dose in patients who develop hypothyroidism after the treatment of Grave’s disease

Answer 3

75-125 ug/d

Question 4

Levothyroxine starting dose for adult patients under 60 yrs old without evidence of heart disease

Answer 4

50-100 ug/d

Question 5

Level of TSH which may require treatment for subclinical hypothyroidism

Answer 5

TSH >10 IU/L

Question 6

Starting does of levothyroxine for subclinical hypothyroidism

Answer 6

25-50 ug/d

Question 7

TSH level of levothyroxine therapy prior to conception of a hypothyroid women

Answer 7

normal range but <2.5 mIU/L

Question 8

Goal TSH of hypothyroid women during pregnancy

Answer 8

lower half of the trimester specific normative range, if available , or <2.5 mIU/L

Question 9

Range of adjustment of levothyroxine dosage if TSH remains high

Answer 9

12.5-25 ug increments every 2-3 months

Question 10

Staring dose of levothyroxine with hypothyroidism in elderly patients , esp with known coronary artery disease

Answer 10

12.5-25 ug/d

Question 11

Levothyroxine dose to treat myxedema coma

Answer 11

Levothyroxine 200-400 ug LD followed by daily oral dose of 1.6 ug/kg/d, reduced by 25% if administered IV

Question 12

Dose of Iiothyronine in the treatment of myxedema coma

Answer 12

Iothyronine 5-20 ug LD followed by 2.5-10 ug q8h

Question 13

Dose of hydrocortisone in the treatment of myxedema coma

Answer 13

Hydrocortisone 50 mg q6h

Question 14

Recommended dose of carbimizole or methimazole in the tx of Graves Disease

Answer 14

Methimazole 10-20 mg every 8-12h

Question 15

Recommended dose of PTU for the tx of Graves disease

Answer 15

PTU 100-200 mg q8h

Question 16

Titration regimen for carbimazole or methimazole

Answer 16

Methimazole or carbimizole - 2.5-10 mg

Question 17

Titration regimen for PTU

Answer 17

PTU 50-100 mg

Question 18

Dose of propranolol

Answer 18

Propranolol 20-40 mg q6h

Question 19

Dose of PTU in thyrotoxic crisis

Answer 19

PTU 500-1000 mg LD and 250 mg q4h - orally or by NGT

Question 20

Dose of methimazole in thyrotoxic crisis

Answer 20

Methimazole 20 mg q6h

Question 21

Dose of Stable iodide in thyrotoxic crisis

Answer 21

5 drops SSKI every 6h

Question 22

Dose of Propranolol in thyrotoxic crisis

Answer 22

Propranolol 60-80 mg q4h or 2 mg IV q4h

Question 23

Dose of Glucocorticoid in thyrotoxic crisis

Answer 23

Hydrocortisone 300 mg iV bolus then 100 mg q8h

Question 24

Dose of aspirin in Subacute thyroiditis

Answer 24

Aspirin 600 mg q4-6h