Thyroid disorders Flashcards

1
Q

THyrotopin alpha is a recombinant form of what?

A

TSH

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2
Q

Most commonly used drug for hyperthyroidism

A

Carbimazole

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3
Q

Symptoms of hyperthyroidism

A

weight loss, heat intolerance, diarrhoea, tacycardia, tremor, sweating, arrhythmias

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4
Q

Laboratory test sign of hyperthroidism

A

HIGH T4 + T3

LOW TSH

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5
Q

What must patients be counselled on whilst taking carbimazole

A

Blood dyscrasias - reporting sore throat, fever, malaise

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6
Q

What is the treatment regime for a thyroid storm (thyrotoxic crisis)

A

emergency treatment with IV fluids, propanolol, hydrocortisone, oral iodine + carbimazole/propylthiouracil

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7
Q

What is the drug of choice to treat hyperthyroidism in pregnancy?

A

Propylthiouracil for the first trimester - carbimazole is associated with congenital affects but can be switched to in the second trimester)

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8
Q

Acute pancreatitis is associated with what hyperthyoidism medication?

A

Carbimazole

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9
Q

Females of child bearing potential on carbimazole should also be prescribed what?

A

Contraception

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10
Q

Severe hepatic reactions have been associated wiht what thyroid medication?

A

Propylthiouracil

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11
Q

What should patients on propylthiouracil be counselled on?

A

Reporting liver failure sx e.g. jaundice, dark urine, pale stools, pruiritus

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12
Q

treatment choice for hypothyriodism

A

Levothyroxiine

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13
Q

Whast should patients be prescribed 10-14 days beofre a partial thyroidectomy?

A

Iodine

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14
Q

Symptoms of hypothyriodism

A

Cold intolerance, weight gain, contipation, bradycardia, letharg, muscle cramps, slow thoughts, thin hair

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15
Q

Laboratory markers of hypothyroidism

A

LOW T3 + T4

HIGH TSH

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16
Q

How is liothyronine different to levothyroxine

A

Metabolised quicker so a more rapid effect - can be used in severe hypothyriod states when a rapid effect is needed

17
Q

Drug of choice in hypothyroid coma

A

Liothyronine IV

18
Q

maximum doses of Levothyroixine

A

200mcg

19
Q

How should levothyroixine be taken

A

In the morning 30 mins before breakfast, caffeine containing liquids or other medications