Thyroid Disorders Flashcards
Which thyroid disease almost exclusively effects felines?
Hyperthyroidism
Give the marked clinical signs for hyperthyroidism?
Increased appetite - increased faecal volume - PD/PU - hyperactive - CVS disease - palpable thyroid nodule
How does hyperthyroidism cause cardiac disease?
Increased triiodothyronine (T3) - decreased systemic vascular resistance - decreased arterial filling volume - increased sodium reabsorption - increased blood volume - increased cardiac ionotropy and chronotropy
What is highly associated with hyperthyroidism? What are the implications of this during treatment?
Hypertension - need to monitor BP during treatment
What are the clinical pathological signs of hyperthyroidism?
Elevated ALT (88% of cases) - Elevated ALP (45% of cases) - Elevated bile acids (65% of cases) - Stress leukogram
What diagnostics can be carried out to confirm hyperthyroidism diagnosis?
Measure total T4 basal level (increased) - Basal free T4 levels - Basal cTSH levels (should be undetectable) - T3 suppression test
What are the 4 main treatments for hyperthyroidism?
Medical treatment - Unilateral thyroidectomy- Bilateral thyroidectomy - Thyroid irradiation
What drugs are used in medical treatment of hyperthyroidism?
Carbimazole - Methimazole
What thyroid disease is almost always associated with dogs?
Hypothyroidism
What is the difference between congenital and acquired hypothyroidism?
Congenital - enzyme deficiencies
Acquired - immune-mediated destruction of thyroid tissues
Give the clinical signs of hypothyroidism?
Lethargy - Exercise intolerant - Muscle/joint pain - Dermal changes (alopecia, thickened skin) - Infertility - Neurological problems
What is the clinical pathology of hypothyroidism?
Mild non-regenerative anaemia - Increased serum cholesterol (60% cases) - Increased serum creatinine kinase (40% cases) - Proteinuria
Which two diagnostics give a good specificity for hypothyroidism?
Total T4 levels and basal TSH levels
What is the treatment for hypothyroidism?
Thyroxine tablets+
