thyroid conditions Flashcards
1
Q
hypothyroidism vs hyperthyroidism
A
hypothyroidism
- aim is to replace thyroid hormone
- causes can be either acquired or defects in production
hyperthyroidism
- blocks thyroid hormone production or secretion
- happens a lot in cats
2
Q
meds used for thyroid replacement therapy (hypothyroidism)
A
L-thyroxine & thyroxine are usually the most used in dogs and cats
triiodothyroxine is recommended for dogs who can’t convert T4 to T3, must monitor when using the meds for the first 2 weeks
3
Q
antithyroid drugs
A
Thionamide drugs: thiamazole & carbimazole
- inactive until converted
- MOA is to inhibit thyroid peroxidase reactions and inhibit the conversion of T4 to T3
4
Q
general points
A
- good oral bioavailability
- adverse effects includes vomiting & anorexia