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Pharm II Test 3 > Thyroid & Anti-Thyroid Drugs > Flashcards

Thyroid & Anti-Thyroid Drugs Flashcards

1
Q

Levothyroxine- Na (L-T4) (Synthroid, Levoxyl, Levothyroid, Unithyroid)- Mech of Action

A

T4 Supplement

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2
Q

Levothyroxine- Na (L-T4) (Synthroid, Levoxyl, Levothyroid, Unithyroid)- Clinical Use

A

hypothyroidism
cretenism
TSH suppression therapy for thyroid cancer
occasionally TSH suppression in nontoxic goiter

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3
Q

Levothyroxine- Na (L-T4) (Synthroid, Levoxyl, Levothyroid, Unithyroid)- Adverse Effects/Contraindications

A

narrow therapeutic window

hyperthyroidism (heat intolerance, agitation, etc.)

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4
Q

Levothyroxine- Na (L-T4) (Synthroid, Levoxyl, Levothyroid, Unithyroid)- Drug Rxns

A

levels are decreased by cyp inducers (phenytoin, rifampin, carbemazepine)

absorption decreased by cholestyramine, iron, Ca supplements, A1OH, and soy products

can increase the action of Warfarin, TCAs, and amiodarone

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5
Q

Liothyronine-Na (L-T3) (Cytomel, Triostat)- Mech of Action

A

T3 supplement

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6
Q

Liothyronine-Na (L-T3) (Cytomel, Triostat)- Clinical Use

A

occasionally used for rapid onset or shorter lasting action: myxedemic coma

Prep for (131)I therapy for thyroid cancer

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7
Q

Liothyronine-Na (L-T3) (Cytomel, Triostat)- Adverse Effects/Contraindications

A

hyperthyroidism

more potent than T4- may have more serious side effects such as cardiac arrhythmias

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8
Q

Liotrix (Thyrolar)- Mech of Action

A

T3 and T4 supplement

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9
Q

Liotrix (Thyrolar)- Clinical Use

A

same as T4

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10
Q

Liotrix (Thyrolar)- Adverse Effects/Contraindications

A

Same as T4

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11
Q

Liotrix (Thyrolar)- Drug Rxns

A

Same as T4

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12
Q

Propylthiouracil (PTU), Methimazole (Tapazole)- Mech of Action

A

INHIBIT IODINE ORGANIFICATION (THE PEROXIDASE CATALYZED IODINATION AND COUPLING RXNS)

PROPYLTHIOURACIL ALSO INHIBITS PERIPHERAL DEIODINATION OF T4 TO T3

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13
Q

Propylthiouracil (PTU), Methimazole (Tapazole)- Clinical Use

A

Hyperthyroidism
Control of elevated T4 in Graves’ disease while awaiting effet of irradiation
Preparation for thyroid surgery

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14
Q

Propylthiouracil (PTU)- Adverse Effects/Contraindications

A

AGRANULOCYTOSIS (NOT DOSE DEPENDENT)
MILD GRANULOCYTOPENIA
MOST COMMON- URTICARIA/RASH

if urticaria/rash occurs, change to methimazole
PREFERRED IN NURSING MOTHERS- VERY LITTLE IN MILK

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15
Q

Methimazole (Tapazole)- Adverse Effects/Contraindications

A

DOSE DEPENDENT AGRANULOCYTOSIS
MILD GRANULOCYTOPENIA
MOST COMMON- URTICARIA/RASH

NOT RECOMMENDED IN NURSING MOTHERS

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16
Q

Iodide (Iodopen)- Mech of Action

A

AT HIGH DOSES INHIBITS IODIDE UPTAKE, AND SYTHESIS OF IODOTYROSINE & IODOTHYRONINE

ALSO INHIBIT HORMONE RELEASE

17
Q

Iodide (Iodopen)- Clinical Use

A

PEOP. FOR HYPERTHYROID STATE
THYROID STORM
PROPHYLACTIC FOR PROTECTION IN RADIATION EXPOSURE

EFFECTS WANE OVER TIME, SO MUST BE USED IN CONJUNCTION WITH OTHER DRUGS.

18
Q

Iodide (Iodopen)- Adverse Effects/Contraindications

A

Hypersensitivity when administered IV- angioedema

19
Q

Radioactive iodide I(131)- Mech of Action

A

NA(131)I IS CONCENTRATED IN THE THYROID WHERE THE BETA AND GAMMA RADIATION WILL DESTROY ALL OR PART OF THE TISSUE

20
Q

Radioactive iodide I(131)- Absorption, Distribution

A

PO

21
Q

Radioactive iodide I(131)- Clinical Use

A

ABLATION THERAPY FOR HYPERTHYROIDISM

Adjuvant therapy with B-blockers or other drugs while awaiting full effectiveness is OK

22
Q

Radioactive iodide I(131)- Adverse Effects/Contraindications

A

OVERTREATMENT RESULTS IN HYPOTHYROIDISM

CONTRAINDICATED IN PREGNANCY, PATIENTS UNDER THE AGE OF 35.

23
Q

Radioactive iodide I(131)- Drug Rxns

A

High dose iodide

24
Q

B-blockers- Mech of Action

A 
INHIBIT DEIODINATION (CONVERSION OF T4 TO T3)
DECREASE HR, CONTRACTILITY, ARRHYTHMIAS
25
Q

B-blockers- Clinical Use

A

THYROID STORM
ADJUVANT TO I-(131)
ACUTE TREATMENT OF HYPERTHYROID STATE- ESPECIALLY THE CARDIAC SIDE EFFECTS (T3 UPREGULATES B-ADRENERGIC RECEPTORS–> INCREASES HR AND CONTRACTILITY)

will not change thyroid hormone levels- changes clinical outcome

Pharm II Test 3 (9 decks)

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