Androgens

Question 1

Testosterone enanthate & Testosterone cypionate- Absorption, Distribution

Answer 1

IM, transdermal, topical, PO

Question 2

Testosterone enanthate & Testosterone cypionate- Clinical Use

Answer 2

Hormone replacement therapy Hypogonadism

Question 3

Testosterone enanthate & Testosterone cypionate- Adverse Effects/Contraindications

Answer 3

Cholestatic jaundice liver carcinoma BPH postate cancer gynecomastia acne headache Contraindicated in breast cancer, prostate cancer, pregnancy if used in women

Question 4

Flutamide- Mech of Action

Answer 4

Competitive inhibition of DHT or T receptor binding

Question 5

Flutamide- Clinical Use

Answer 5

metastatic prostate cancer BPH Better than DES and Leuprolide in treatment of prostate cancer

Question 6

Flutamide- Adverse Effects/Contraindications

Answer 6

hepatotoxicity hematopoietic disorders diarrhea nausea rash hot flashes Contraindicated in severe hepatic impairment

Question 7

Spironolactone- Mech of Action

Answer 7

Competitive inhibition of DHT or T receptor binding Also an aldosterone receptor antagonist

Question 8

Spironolactone- Clinical Use

Answer 8

hirsutism hypertension acne vulgaris edema associated with heart failure cirrhosis or nephrotic syndrome hypokalemia

Question 9

Spironolactone- Adverse Effects/Contraindications

Answer 9

GI hemorrhage hyperkalemic metabolic acidosis agranulocytosis systemic lupus erythematosis gynecomastia dyspepsia lethargy abnormal menstruation impotence rash breast cancer (?) Contraindicated in anuria, hyperkalemia, acute renal insufficiency

Question 10

Testosterone enanthate & Testosterone cypionate- Mech of Action

Answer 10

Replacement of testosterone–> produces androgenic effects: prostate, seminal vesicles, penis & scrotum, male hair distribution, laryngeal development, vocal cord thickening, alteration of musculature, fat distribution

Question 11

Finsteride- Mech of Action

Answer 11

Type II 5 a-reductase inhibitor–> prevent conversion of T to DHT in prostate, liver, and skin

Question 12

Finsteride- Clinical Use

Answer 12

BPH androgenic alopecia Used as alternative to transurethral resection of prostate

Question 13

Finsteride- Adverse Effects/Contraindications

Answer 13

neoplasm of male breast breast tenderness decreased libido erectile dysfunction ejaculatory disorder Contraindicated in known or suspected pregnancy