thyroid Flashcards
hypothyroid treatment
levothyroxine
1 pituitary hypothyroid cause
hypopituitarism form non functioning adenoma
thyroid causes of hypothyroid
Thyroidectomy
post radioactive iodine ablation
Autoimmune
thyroiditis- postpartum, silent, Hashimoto’s
blocking TSH receptor antibodies
2 congenital causes of hypothyroid
Thyroid dysgenesis (85%) Dyshormonogenesis
4 causes of Dyshormonogenesis
Thyroid peroxidase
thyroglobulin
sodium iodide symporter
pendrin (Pendred syndrome) - deafness and hypothyroidism
Maternal thyroid disease
Neonatal hypothyroidism/cretinism
symtoms
- Coarse facial features
- Macroglossia
- Large fontanelles
- Umbilical hernia
- Mottled, cool, and dry skin
- Developmental delay
- Pallor
- Myxedema
- Goiter
Hyperthyroidism
Investigation
TSH - free T4 and total T3
TSH receptor antibodies
TPO- thyroid peroxisomal antibody
123 I uptake scan
Hyperthyroidism symtoms
Eye symptoms
Petibial myxedma
Thyroid acnopalsty
Treatment of hyperthyroid
Beta blockers
Carbimazole 40 mg daily (propylthiouracil)
OR
131I (radioactive iodine)
pituitary cause of hyperthyroid
Pituitary adenoma
other hormone acting as TSH causing hypothyroid
HCG
Thyroid causes of hyperthyroid
Autoimmune
thyroid adenoma
what gives a thyroid bruit
graves
how does amidoarone work
Amiodarone - releases iodine , good for AF
Jod Basedow phenomenon:
iodine induced hyper thyroidism
Wolff Chaikoff effect
iodine induced hypo thyroidism
Amiodarone thyroid disease
type 1
and treatment
autoimmune thyrotoxicosis - unmasking a previous thyroid disease
treatment high dose carbimazole
Amiodarone thyroid disease
type 2
and treatment
destructive thyroiditis
treatment glucocorticoids / steroids
Proptosis increases risk of
corneal ulceration
what kind of cancer if thyroid c cell
medullary cancer
4 thyroid carcinomas
Papillary
Follicular
Anaplastic
Poorly Differentiated
Meduallary thyroid cancer
Cancer of parafollicular (calcitonin) producing thyroid cells
Familial
3 diseases associated with Mutations of RET protoncogene
Familial Medullary Thyroid Cancer
Multiple Endocrine Neoplasia type 2 and 3 (MTC, phaeochromocytoma, primary hyperparathyroidism)
Hirschprungs
