Thursday CBL anticancer drugs Flashcards
Temozolomide
Mech Administration Side effects cross BBB? CCS? Lipophilic? effected by efflux pumps? Size?
a. Mechanism: Alkylating Agent (adds alkyl groups to the DNA), antineoplastic, interferes with DNA replication; attaches and alkylates guanine= cross link between bases
b. Administration: Oral
c. Can cause non-Hodgekin’s lymphoma (case A)
d. Can cross the BBB- small and lipid soluble
e. not cell cycle specific
f. Lipophilic
g. not effected by efflux pumps
h. small in size
5 - FU
Mech?
Inhibits nucleotide synthesis, stops formation of uracil.
Methotrexate
Mech?
delivery?
cross BBB?
inhibits synthesis of folate, which inhibits synthesis of glutamate.
intrathecally (into the space between spinal cord and spinal column)
doesn’t cross BBB
ARA - C
Mech
Inhibits pyrimidine synthesis
Fludarabine
Mech
inhibits purine synthesis
Cyclophosphamide
mech
crosslinks and damages DNA
BCNU
other name? mech? cross BBB? NU stands for...? small/large? lipophilic? affected by efflux pumps?
Carmustine cross-links DNA Crosses BBB NU stands for nitrosourea - all drugs with this cross BBB Large somewhat lipophilic indifferent to efflux pumps...?
Vincristine
Mech
size
lipophilic?
affected by efflux pumps in brain?
Decreases spindle formation
Large
Lipophilic
affected by efflux pumps
Amphoterecine B
used for?
Small/large?
lipophilic?
efflux pumps?
fungal infections
large
lipophilic
affected by efflux pumps
dexamethazone
four things it does
a. immunosuppressant
b. decrease swelling in the brain
c. reconstitutes the BBB
d. antiemetic
cyclophosphamide
Mech?
CCS?
crosslinks DNA
CCNS
cisplatin
Mech?
CCS?
crosslinks DNA
CCNS
doxorubicin
Mech?
CCS?
intercalates into DNA
CCNS
etoposide
Mech?
CCS?
Strand breaks
CCNS
Two anti-cancer drungs that are cell cycle specific
paclitaxel - increase spindle formation
vincristine - decrease spindle formation
