Thursday 1 - Trachte - Arachadonic acid metabolites

Question 1

NSAID’s inhibit the synthesis of what?

Answer 1

Prostaglandins from arachadonic acid.

Question 2

Which enzyme is most likely to release arachidonic acid from the membrane

Answer 2

Phospholipase A2

Question 3

4 things that prostaglandins are made into from class

Answer 3

PGE2
PGF2
Prostacyclin
Thromboxane

Question 4

This arachadonic product causes inflamation, increased capillary permeability.

Answer 4

PGE2

Question 5

This arachadonic product signals for the start of your period, along with menstrual pain.

Answer 5

PGF2

Question 6

This arachadonic product inhibits clotting and prevents M.I.s

Answer 6

Prostacyclin

Question 7

This arachadonic product causes blood clotting and potentially M.I.s

Answer 7

Thromboxane A2

Question 8

COX2 inhibitors primarily block this arachidonic acid metabolite.

Answer 8

Prostacyclin

Question 9

This will be at the end of the drug name if it is a COX2 inhibitor

Answer 9

“coxib”

ie celecoxib (celebrex)

Question 10

3 Cyclooxygenase inhibitors (NSAIDS)

Answer 10

Acetylsalicylic acid (asprin)
Celecoxib (celebrex)
Ibuprofen

Question 11

4 Corticosteroids

Answer 11

Dexamethasone
Hydrocortisone
Methylprednisolone
Prednisone

Question 12

Non antiinflam. COX inhibitors

Answer 12

Acetaminophen

Question 13

5 things corticosteroids inhibit

Answer 13

Arachidonic acid, IL-1, IL-6, TNF, leukotrienes

they are transcriptional regulators

Question 14

Side effects of corticosteroids

Answer 14

osteoporosis
immune suppression
peptic ulcers
myopathy
cataracts
fluid accumulation, hyperglycemia

Question 15

What general class of drug inhibits both prostaglandins and leukotrienes?

Answer 15

Corticosteroids

Question 16

Leukotrienes

Answer 16

participate in allergic responses such as asthma

Question 17

What selectively prevents leukotriene synthesis?

Answer 17

Zileuton

Question 18

Relieves arthritis and reduces risk of MI?

Answer 18

acetylsalicylic acid

Question 19

Effective arthritis treatment with least risk of gastric ulceration?

Answer 19

celecoxib (celebrex)

Question 20

What F.A. may cause a bleeding tendency and resistance to M.I.

Answer 20

Fish oil (eicosapentaenoic acid)

Question 21

How do you treat the SYMPTOMS of rheumatoid arthritis?

Answer 21

inhibit prostaglandin synth. this only treats symptoms

Question 22

Major effects of corticosteroids

Answer 22

reduction in WBC

reduction in arachidonic acid liberation