Thrombopoisis

Question 1

General

Answer 1

Platelets anuclear fragments of megakaryocytes

Smallest formed elements

Question 2

Thrompoi Stage

Answer 2

Megacarblast form –stem cell

Megcypois–pro, baso, granu, Mature

Platlet form

Question 3

Stem cells

Answer 3

Myloid sc
CFU mega
Mblast

Question 4

Megkarblast

Answer 4

First id
Basophilic
Multilobe nucleus

Question 5

Megkcyte

Answer 5

Promegkcyte
Granular meg
Mature meg

Question 6

Promegkcyte

Answer 6

Bigger than blast
Horse shoe shape nucleus
Azurophilic granules around centrosome
Also baso meg

Question 7

Granulaer megkcyte

Answer 7

Acidophilic,
Azurophilic granules around nucl
Irregular and h-shoe nucl

Question 8

Mature megkcyte

Answer 8

Largest in marrow
Polyploid b.marrow cells
Large cell
Granu-4-alpha, dense, lysosomal, myleoidperoxidase
Granules around nucl
Nucl size reduce
1 demand 1 size

Question 9

Thrompois regulation

Answer 9

Const production…rem-more, put-red
Thropoitin
Interluling
GM-CSF

Question 10

Thrombopoitin

Answer 10

Liver, some kidney
Shortlived

Recombu-ecoli-20/40 hrs
Diff and prolif megcytes

Question 11

Interlukins

Answer 11

I- 1, 3, 6, 11…..platelt prod

Not thropoitin release

Question 12

GM-CSF

Answer 12

Prod by monocytes, T-lympho, fibroblast and endo cells

Erythro, granulo and thrpoisis stimulated

Question 13

Life of platelet

Answer 13

Half life -4 days
8-12 days in circulation
Rem by reticuloendothelial cells
Spleen-distruction
Count 1 after spleenctomy
            Dec after spleenomegaly