Thrombolytics Flashcards
1
Q
What is the MOA of Thombolytics?
A
Basically to just turn Plasminogen to Plasmin, which will affect the cross-linked fibrin. Causing the clot to dissolve.
-can increase bleeding risk
2
Q
What are the two things need to activate plasminogen to plasmin?
A
XIIa and t-PA
-t-PA is inhibited my PAI-1 and PAI-2
3
Q
What is Alteplase?
A
Thrombolytic Drug used for Acute MI, Stroke, and PE.
-Short t1/2
-cleared in the liver & kidney
4
Q
What is streptokinase?
A
a catalyst that converts plasminogen to plasmin BUT it doesn’t direct dissolve clots.
