Lipid Junk Flashcards
Which class of Lipoprotein has the most Triglycerides?
Chylomicins; VLDL is a close second
What class of Lipoproteins has the highest amount of Cholesterol?
LDL
Which class of Lipoproteins has the highest amounts of Proteins?
HDL
What enzyme helps breakdown chylomicins and VLDL within the capillaries?
Lipoprotein Lipase
What is the Apoprotein found on HDL?
Apo-A
Where are Apo-B found?
Apo-B 100: VLDL, LDL, IDL; Apo-B 48: Chylomicins
What are the ranges of Total Cholesterol?
Desirable: <200; Elevated: 200-249; High: >250
What are the ranges for LDL?
Desirable: <130; Elevated: 130-159; High: >160
What are the ranges for HDL?
[All are good] Desirable: Men - <40 & Female - <50 High: <60
What are the ranges for TGs?
Desirable: <150; Elevated: 150-199; High: >200
What medications are the Statins?
Lovastatin, Atrovastatin, Fluvastatin, Rosuvastatin, Simvastatin, Pravastatin, Pitavastatin
What is the MOA for the Statins?
HMG-COA Reductase Inhibitors; Basically they completely inhibit the HMG-COA enzyme which causes the DECREASE in cholesterol synthesis. This DECREASE will either; INCREASE the expression of LDL-R, causing an INCREASE of the re-uptake of LDL from the blood OR it will DECREASE the release of VLDL = DECREASING LDL. [Both will decrease LDL levels].
Which Statins are Prodrugs?
Lovastatin and Simvastatin
CYP interactions with Statins?
3A4: Simvastatin, Lovastatin, Atorvastatin
- Avoid: Grapefruit, Ketoconazole
2C9: Rosuvastatin, Fluvastatin
- Avoid: Metronidazole, cimetidine, amioridone
N/A: Pravastatin, Pitvastatin
Time sensitivities with Statins?
Short Half-Life: Lovastatin, Simvastatin, Fluvastatin
- Taken at night or Bedtime
Slow Release: Atorvastatin, Pravastatin, Rosuvastatin
-Taken at any time
How does food affect absorption within Statins?
Lovastatin, Simvastatin: Take with food to INCREASE absorption
Pravastatin, Pitavastatin: Take with food will DECREASE absorption
Which Statins are Lipophilic and which are Hydrophilic?
Hydrophilic: Rosuvastatin, Pravastatin
Lipophilic: Simvastatin, Atorvastatin, Lovastatin, Fluvastatin, Pitavastatin