Thrombolytic/Antiplatelet agents

Question 1

Thrombolysis in AMI, ischemic CVD and PE

Answer 1

Alteplase

Question 2

SE: bleeding

Answer 2

Alteplase

Question 3

Bacteria-derived thrombolytic, decreased effect on subsequent uses due to antibody formation

Answer 3

Streptokinase

Question 4

Antidote to thrombotic overdose

Answer 4

Tranexamic Acid

Question 5

Irreversible COX inhibitor, instant prevention of arterial thrombosis

Answer 5

Aspirin

Question 6

SE: tinitus, hypersensitivity, Reyes syndrome

Answer 6

Aspirin

Question 7

ADP inhibitor, Additive effects with Aspirin

Answer 7

Clopidogrel

Question 8

Glycoprotein IIb-IIIa inhibitor

Answer 8

Abciximab

Question 9

Phosphodiesterase inhibitor, Cardiac stress testing

Answer 9

Dyprimadole

Question 10

How many 500mg Aspirin tablets must be ingested to produce toxicity?death?

Answer 10

Toxic dose 150mg/kg = 21 tabs

Lethal dose = 500mg/kg = 70 tabs in a 70 kg man

Question 11

What is the triad of aspirin hypersensitivity?

Answer 11

Asthma
Apirin Hypersensitivity
Nasal Polyps

Question 12

What are the signs of ASA poisoning?

Answer 12

Coma
Hyperventilation
Acidosis
Fever
Seizure

Question 13

What is the expected acid-base abnormality in salicilate poisoning?

Answer 13

Respiratory alkalosis