Anticoagulants

Question 1

Acute treatment of DVT, PE and AMI

Answer 1

Heparin

Question 2

SE: bleeding, thrombocytopenia, monitor with PTT

Answer 2

Heparin

Question 3

LMWH, less risk of thrombocytopenia, does not need monitoring

Answer 3

Enoxaparin

Question 4

Treatment of heparin induced bleeding

Answer 4

Protamine sulfate

Question 5

Chronic anticoagulation

Answer 5

Warfarin, Vit K epoxidase inhibitor

Question 6

SE: bleeding, skin necrosis, many drug interactions

Answer 6

Warfarin

Question 7

Antidote to warfarin (immediate reversal)

Answer 7

Vit K

Question 8

What laboratory tests will you request to assess the extrinsic and intrinsic coagulation pathways?

Answer 8

PiTT
PTT for Intrinsic pathway
PeT
PT for Extrinsic pathway

Question 9

In patients requiring anticoagulation, why is an overlap between heparin and warfarin usually done?

Answer 9

1. warfarin’s effect requires elimination of preformed clotting factors (8-60h)
2. to bypass the initial prothrombotic effect of warfarin (skin necrosis)

Question 10

Large acidic polysaccharide

Answer 10

Heparins

Question 11

Small lipid-soluble molecule

Answer 11

Warfarin

Question 12

Site of action of
Heparin:_____
Warfarin:____

Answer 12

Heparin: blood
Warfarin: Liver

Question 13

Rapid Onset

Answer 13

Heparin

Question 14

Impaires post transitional modification of Factors II VII IX X (Vit K dependent

Answer 14

Warfarin

Question 15

Activates Antithrombin III

Answer 15

Heparin

Question 16

PTT monitoring

Answer 16

Heparin

Question 17

PT monitoring

Answer 17

Warfarin

Question 18

Can be used in pregnancy

Answer 18

Heparin