Thrombocytosis

Question 1

What are the two type of thrombocytosis

Answer 1

Thrombocytosis is categorized as either:
- primary thrombocytosis: a rare myeloproliferative neoplasia

- secondary or reactive thrombocytosis

Question 2

What is the pathomechanism for secondary thrombocytosis

Answer 2

The number of circulating peripheral platelets is increased either by redistribution or through incresaed production secondary to an underlying disease process:
- physiologic conditions causing an increase in catecholamines can result in thrombocytosis (e.g., stress, anxiety)

- non-neoplasic inflammatory disease is the most common cause (GI disease seems the most commonly diagnosed condition)

- multicentric lymphoma and gastrointestinal lymphoma were more commonly diagnosed in cats with thrombocytosis in one study

- hepatobiliary diseases
    - liver is the primary site of thrombopoietin synthesis
    - it is possible that chronic hepatobiliary disease could lead to an increase in thrombopoietin production

- immune-mediated diseases