Hemophagocytic histiocytic sarcoma

Question 1

What is then origin for histiocytic diseases

Answer 1

Histiocytic diseases derive from either dendritic or macrophagic lineage
- macrophages represent the lineage involved with the hemophagocytic syndrome

Question 2

How frequent are histiocytic diseases in cats

Answer 2

Histiocytic disease is extremely rare in cats

The most well-documented histiocytic syndrome in cats is feline progressive histiocytosis
- it is mainly due to a proliferation of Langerhans cells
- most frequently causes skin lesions (e.g., crusts, cutaneous nodules/masses of epithelial origin)
- it has a slower progression than histiocytic sarcoma
- feline progressive histiocytosis does not typically involve the spleen

Question 3

What are the clinicopathological findings in histiocytic sarcoma

Answer 3

Regenerative or non-regenerative anemia

Thrombocytopenia

Hyperbilirubinemia

Lymphopenia

+/- leukocytosis with marked neutrophilia

CD 18 and CD 204 immunohistochemistry which are consistent with hemophagocytic sarcoma if positive

Question 4

What is the treatment for hemophagocytic histiocytic sarcoma

Answer 4

Splenectomy

Lomustine

Prednisolone may lead to faster tumor progression (dog’s studies)