throat infections Flashcards

1
Q

what is tonsillitis

A

Immune deficiency and a family history of tonsillitis or atopy

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2
Q

causes of tonsillitis

A
Bacterial
-	Beta haemolytic streptococci
-	Staphylococci
-	Streptococcus pneumonia
-	Haemophilus influenzae
-	Escherischia coli
Viral
-	Rhinovirus
-	Adenovirus
-	Enterovirus
-	EBV
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3
Q

symptoms of tonsillitis

A
  • Severe and may last more than 48 hours along with pain on swallowing
  • Referred to the ears the pain – otalgia
  • Headache
  • Loss of voice or changes in the voice
  • Dysphagia
  • Odynophagia
  • Trismus
  • Halitosis
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4
Q

signs of tonsillitis

A
  • The throat is reddened, the tonsils are swollen and may be coated or have white flecks of pus on them.
  • Possibly a high temperature - pyrexia
  • Swollen regional lymph glands.
  • Classical streptococcal tonsillitis has an acute onset, headache, abdominal pain and dysphagia.
  • Examination shows intense erythema of tonsils and pharynx, yellow exudate and tender, enlarged anterior cervical glands.
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5
Q

DD for sore throat

A
  • Common cold
  • Coxsackievirus – small blisters develop on the tonsils and the roof of the mouth – erupt followed by a scab which are painful
  • Glandular fever – very large and purulent tonsils, enlarged spleen
  • HSV
  • EPGLOTTIS EMERGENCY
  • Unilateral enlargement – indicate malignancy
  • HIV – cervical lymphadenopathy, oroesophageal candidiasis and otitis media
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6
Q

diagnosis for tonsillitis

A

Centor criteria
- History of fever
- Tonsillar exudates
- No cough
- Tender anterior cervical lymphadenopathy
3 OR 4 THEN ITS MORE LIKELY A BACTERIAL INFECTION

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7
Q

Abx for tonsillitis

A

WHEN TO GIVE Abx – 5-10 DAY COURSE PHENOXYMETHYLPENICILLIN ALTERNATIVE CALRITHROMYCIN
NO AMOXICILLIN AS THIS WILL CAUSE A MACULOPAPULAR RASH IN THE PRESENCE OF EBV

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8
Q

indications for ABx for tonsillitis

A
  • Features of marked systemic upset secondary to the acute sore throat.
  • Unilateral peritonsillitis.
  • A history of rheumatic fever.
  • An increased risk from acute infection (such as a child with diabetes mellitus or immunodeficiency).
  • Acute tonsillitis with three or more Centor criteria present (see ‘Diagnostic criteria’, above).
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9
Q

referring a tonsillitis patient

A
  • Breathing difficulty.
  • Clinical dehydration.
  • Peritonsillar abscess or cellulitis, parapharyngeal abscess, retropharyngeal abscess, or Lemierre’s syndrome (as there is a risk of airway compromise or rupture of the abscess).
  • Signs of marked systemic illness or sepsis.
  • A suspected rare cause such as Kawasaki disease, diphtheria, or yersinial pharyngitis.
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10
Q

when to consider tonsillectomy

A

7 episode in a year or 5 per year for 2 years or 3 per year for 3 years REFER TO ENT SPECIALIST
• Sore throats are due to acute tonsillitis.
• The episodes of sore throat are disabling and prevent normal functioning.
• Suspected malignancy
• Presence of sleep apnoea
• Two previous peritonsillar abscesses

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11
Q

surgical methods used in tonsillectomy

A
  • Cold steel - this is the traditional method which involves removal of the tonsils by blunt dissection followed by haemostasis using ligatures.
  • Diathermy - this uses radiofrequency energy applied directly to the tissue. It can be bipolar (the current passes between the two tips of the forceps) or monopolar (the current passes between the forceps’ skin and a plate attached to the patient’s skin). The heat generated may be used to dissect the tonsils away from the pharyngeal wall and also to promote haemostasis. Diathermy is sometimes used as an adjunct to cold steel surgery to achieve haemostasis.
  • Coblation - this involves passing a radiofrequency bipolar electric current through normal saline. The resulting plasma field of sodium ions can be used to dissect tissue by disrupting intercellular bonds and causing tissue vaporisation. This method generates less heat than diathermy.
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12
Q

complications for tonsillitis

A

•otitis media
quinsy - peritonsillar abscess
rheumatic fever and glomerulonephritis very rarely

Peritonsillar abscess.
• Acute otitis media.
• Lancefield’s GABS can cause rheumatic fever, Sydenham’s chorea, glomerulonephritis and scarlet fever.
• Streptococcal infection may cause a flare-up of guttate psoriasis.
• Enlarged and chronically infected tonsils interfere with children’s sleep[11].
• Complications of tonsillectomy include otitis media and haemorrhage which can be very difficult, especially where there is an undiagnosed bleeding tendency such as haemophilia. Altered taste sensation has been reported
• Patients who have had tonsillectomy are more susceptible to bulbar poliomyelitis.
• Deep space neck infection
o Parapharyngeal – CT SCAN WITH IV CONTRAST GOLD STANDARD
o Reteropharyngeal
 Reduced neck movement, cervical pain or torticollis

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13
Q

what is quinsy

A

Peritonsillar abscess is a complication of acute tonsillitis, where a collection of pus forms in the peritonsillar space. This pushes the affected tonsil inferomedially into the oropharyngeal space.

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14
Q

red flags of throat

A
  • Severe sore throat, hoarse/croaky voice, severe dysphagia and fever is epiglottitis until proven otherwise. Stridor may be a late sign and patients can decompensate rapidly.
  • Beware of severe sore throat with severe dysphagia - without any signs of tonsillitis/pharyngitis in the oropharynx. This should be treated as epiglottitis until proven otherwise.
  • Rarely, patients with quinsy can present with profound sepsis.
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15
Q

clinical features of quinsy

A
  • Sore throat
  • +/- otalgia
  • ‘thick’ or ‘hot potato’ voice (NOT HOARSE OR CROAKY VOICE)
  • Stretor sounds like snoring
  • Trismus
  • Inability to swallow more than saliva or a sip or water
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16
Q

differentiate between quinsy v tonsillitis

A
  • There frequently a degree of trismus
  • On the affected side, the anterior arch will be pushed medially
  • On the affected side, the palate will bulge towards you ie the normally concave palate becomes convex
  • The uvula may be pushed away from the affected side
  • On the affected side, the mucosa of the arch and palate may look angrily erythematous
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17
Q

Why is it important to recognise Quinsy?

A
  • Become complicated and cause deep neck space infections – AIRWAY EMERGENCIES
  • Recognise peritonsillar abscess as you usually need aspiration
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18
Q

manage quinsy

A
  • Abscesses – aspiration following topical anaesthetic or incision and drainage with further opening via use of Tileys’ forceps
  • Sometimes if unsure just warn it may be a “dry tap”
  • If difficult to open mouth

o IV treatment

  • IV access
  • FBC, U&Es, LFTs, glandular fever screen
  • Regular basic IV/PO analgesia e.g. paracetamol and ibuprofen, with stronger PRNs
  • Topical analgesic spray e.g. benzydamine spray
  • Fluid resuscitation - the vast majority of patients are young and dehydrated, and perk up after 1L of normal saline
  • Some surgeons prescribe a single dose of steroid (eg 6.6mg dexamethasone IV) to kick-start recovery, especially in those who have stertor
  • Advise those with increased snoring or stertor to sleep semi-upright
  • TONSILLECTOMY CONSIDERED AFTER IN WEEKS
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19
Q

what is laryngitis

A

inflammation of the mucosa lining the vocal folds and larynx

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20
Q

causes of acute laryngitis

A
Viral infection:
Rhinoviruses
Adenoviruses
Influenza viruses
Parainfluenza viruses
Herpes viruses
HIV
Coxsackievirus
Bacterial infection - may co-exist with viral infection:
Haemophilus influenzae type B.
Streptococcus pneumoniae.
Staphylococcus aureus.
Group B beta-haemolytic streptococci.
Moraxella catarrhalis.
Klebsiella pneumoniae.
Less commonly in the developed world, mycobacterial and syphilitic infection.

Fungal Infection:
Candidiasis.
Immunosuppression and the use of steroid inhalers are risk factors.

Trauma:
Trauma due to voice misuse - screaming, yelling, loud singing.
Trauma due to excessive voice use - more common in certain professions such as teachers, actors and singers.
Coughing.
Penetrating or blunt external force.
Habitual throat clearing.

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21
Q

causes of chronic laryngitis

A

Allergy - allergic rhinitis, asthma.

Laryngopharyngeal reflux.

Trauma

Smoking

Autoimmune disease - chronic laryngitis may be a feature of systemic disease in conditions such as rheumatoid arthritis, systemic lupus erythematosus, amyloidosis, pemphigoid.

Sarcoidosis.

Medication
Angiotensin-converting enzyme (ACE) inhibitors by causing cough.
Inhaled steroids by promoting fungal infection.
Antihistamines, anticholinergics and diuretics - all by resulting in drying of the mucosa.
Bisphosphonates by causing a chemical laryngitis.
Danazol and testosterone.

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22
Q

symptoms of acute laryngiitis

A

Hoarseness or a breathy voice.

Pain or discomfort anteriorly in the neck.

MAY 
Symptoms of upper respiratory tract infection (cough, rhinitis).
Dysphagia.
Globus pharyngeus (feeling of a lump in the throat).
Continual throat clearing.
Myalgia.
Fever.
Fatigue and malaise.
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23
Q

what do you do if symptoms persist more than 3 weeks

A

indirect laryngoscopy

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24
Q

DD for acute laryngitis

A

Early chronic laryngitis.

Spasmodic dysphonia.

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25
Q

DD for chronic laryngitis

A

Nodules, polyps and cysts affecting the vocal cords.
Malignancy - laryngeal cancer, lymphoma, thyroid cancer, lung cancer.
Chondronecrosis of the larynx.
Glottic or subglottic stenosis.
Iatrogenic vocal cord scar.
Medication side effect - eg, antipsychotics can cause laryngeal dystonia, warfarin increases the risk of haematoma, drying effect of anticholinergics, etc.
Vascular lesions of the vocal cords.
Laryngeal nerve palsy.
Idiopathic ulcerative laryngitis (prolonged ulceration of the mid-membranous vocal folds, cause unknown)

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26
Q

features seen on indirect laryngoscopy

A

find redness and small dilated vasculature on the inflamed vocal folds.

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27
Q

what is glandular fever

A

infection most commonly caused by the Epstein-Barr virus (EBV)

28
Q

how is glandular fever transmited

A

contact with saliva, usually from asymptomatic carriers, such as through kissing or sharing food and drink utensils

sexual contact

29
Q

complications of glandular fever

A
hepatits
upper airway obstruction
cardiac complications
renal complications
neuro complications - encephalitis
haem complications - mild thrombocytopenia
splenic rupture
chronic fatigue
cancer esp lymphoproliferative - hodgkin's lymphoma + Burkitt lymhoma
MS
Abnormal LFTs
30
Q

type of renal complications seen in EBV

A

interstitial nephritis, myositis-associated acute kidney injury, haemolytic uraemic syndrome, and jaundice-associated nephropathy

31
Q

type of neuro complications seen in EBV

A

aseptic meningitis, facial nerve palsy, transverse myelitis, Guillain-Barré syndrome, and optic neuritis

32
Q

when to suspect glandular fever

A

fever
lymphadenopathy - bilateral posterior cervical lym
sore throat

33
Q

Ix for EBV suspicion

A

immunocompetent adutlts

- FBC + monospot test

34
Q

DD for glandular fever like symptoms

A

cytomegalvirus - splenomegaly, hepatomegaly, and a negative monospot test. NO SORE THRAOT or LYMPHADENOPATHY

Acute toxoplasmosis

Acute viral hepatitis — may cause malaise, fever, lymphadenopathy, and atypical lymphocytosis.

Primary HIV infection — may present with pharyngitis, fever, and lymphadenopathy, rash, diarrhoea, weight loss, nausea, and vomiting.

Rubella — may rarely present with fever, lymphadenopathy, and atypical lymphocytosis

Mumps — typically presents with parotitis and there may be low-grade fever and malaise

Herpes simplex virus-1 — typically presents with acute onset of symptoms and high fever with myalgia, arthralgia, and cough.

35
Q

when to refer an EBV patient urgently

A

Develop stridor or respiratory difficulty.
Have difficulty swallowing fluids or have signs of dehydration, such as reduced urine output.
Become systemically very unwell.
Develop abdominal pain (may indicate splenic rupture).

36
Q

features seen in children with adenoidal hypertrophy

A

nasal obstruction

nasal discharge.

37
Q

indications for adenoidectomy

A

OME
chronic nasal obstructions and discharge
sleep apnoea with tonsillectomy

38
Q

contradictions for adenoidectomy

A

bleeding disorders
recent pharyngeal infection
short or abnormal palate

39
Q

complications of adenoidectomy

A

reactionary haemorrahge
persistent nasal bleeding
haematemesis

40
Q

common oral lesions

A

herpes labialis

recurrent aphthous stomatits

41
Q

what is mumps

A

acute infectious disease caused by a paramyxovirus characterised by bilateral parotid swelling.

42
Q

how is mumps spread

A

respiratory droplets, fomites or saliva, and replicates mainly in the upper respiratory mucosa.

43
Q

complications of mumps

A

parotitis

  • obstruction of lymph drainage
  • sialectasia or sialadenitis

epididymo-orchitis - infertility?

encephalitis

oophoritis

aseptic meningitis

transient hearing loss

myocardial complications

pancreatitis

spontaneous abortion

44
Q

diagnosis of mumps

A

clinical

laboratory saliva - detect immunoglobulin

45
Q

when to suspect mumps

A

parotitis

low-grade fever, headache, earache, malaise, muscle ache, and loss of appetite

46
Q

other causes of parotitis

A

infection - viral - EBV. parovirus B19

acute suppurative parotitis - staph aureus

Non infection cause
parotid duct obstrcution - salivary stones, cysts or tumours

drugs - thiazides, phenothiazines, thiouracil

metabolic disorders - diabetes, cirrhosis, uraemia

autoimmune disease - sarcoidosis, sjogrens, wegner’s

47
Q

what is croup

A

sudden onset of a seal-like barking cough, often accompanied by stridor, voice hoarseness, and respiratory distress.

48
Q

risk factors for croup

A

6 months - 6 years
male
previous intubation

49
Q

diagnosis for croup

A

seal-like barking cough
stridor
chest wall (intercostal) or sternal indrawing.
worse at night and increase with agitation.

coryza, non-barking cough, mild fever) may have been present for between 12 and 48 hours.

hoarse voice

50
Q

DD for croup

A

bacterial tracheitis

epiglottitis

foreign body in upper way

quinsy

angioneurotic oedema - dyspnoea and stridor

allergic reaction

51
Q

management if croup

A

dexamethasone

52
Q

what is pertussis/whooping cough

A

infectious disease caused by the bacterium Bordetella pertussis

sharp inhalation of breath during bouts of paroxysmal cough.

53
Q

complications of whooping cough

A

Apnoea.
Pneumonia (usually caused by secondary bacterial infection).
Seizures.
Encephalopathy (rare in adults).

prolonged coughing can cause:
Pneumothorax.
Umbilical and inguinal hernias, and rectal prolapse.
Rib fracture and herniation of lumbar intervertebral discs.
Urinary incontinence.
Subconjunctival or scleral haemorrhage, and facial and truncal petechiae.

54
Q

name the 3 phases of whooping cough

A

catarrhal phase

paroxysmal phase

convalescent phase

55
Q

what is the catarrhal phase (pertussis)

A

lasts between one and two weeks.

Nasal discharge.
Conjunctivitis.
Malaise.
Sore throat.
Low-grade fever.
Dry, unproductive cough.
56
Q

what is paroxysmal phase

A

1 week after the catarrhal

duration 1-6 weeks

Typically consist of a short expiratory burst followed by an inspiratory gasp, causing the ‘whoop’ sound

more common at night

thick mucous plugs or watery secretions

57
Q

what is the convalescent phase

A

lasts up to 3 months, during which there is a gradual improvement in cough frequency and severity.

58
Q

how to make clinical diagnosis of whooping cough

A

acute cough that has lasted for 14 days or more without another apparent cause, and has one or more of the following features:
Paroxysmal cough.
Inspiratory whoop.
Post-tussive vomiting.
Undiagnosed apnoeic attacks in young infants.

59
Q

management of whooping cough

A

onset of cough within 21 days

macrolide
1st line

Prescribe clarithromycin for infants less than 1 month of age.

Prescribe azithromycin or clarithromycin for children aged 1 month or older, and non-pregnant adults.

erythromycin for pregnant women

co-trimoxazole if macrolide contradicted

60
Q

what medication can increase salivation

A

pilocarpine

61
Q

pilocarpine side effects

A
Sweating.
Dizziness.
Runny nose.
Blurred vision.
Frequent trips to pass urin
62
Q

what is the centor criteria

A

presence of tonsillar exudate
tender anterior cervical lymphadenopathy or lymphadenitis
history of fever
absence of cough

63
Q

define fever pain score

A
Fever over 38°C.
Purulence (pharyngeal/tonsillar exudate).
Attend rapidly (3 days or less)
Severely Inflamed tonsils
No cough or coryza
64
Q

indications for tonsillectomy

A

sore throats are due to tonsillitis (i.e. not recurrent upper respiratory tract infections)

the person has five or more episodes of sore throat per year
symptoms have been occurring for at least a year

the episodes of sore throat are disabling and prevent normal functioning

65
Q

other established indications for tonsillectomy

A

recurrent febrile convulsions secondary to episodes of tonsillitis

obstructive sleep apnoea, stridor or dysphagia secondary to enlarged tonsils

peritonsillar abscess (quinsy) if unresponsive to standard treatment

66
Q

differentials of tonsiliitis

A
  • Common cold
  • Coxsackievirus – small blisters develop on the tonsils and the roof of the mouth – erupt followed by a scab which are painful
  • Glandular fever – very large and purulent tonsils, enlarged spleen
  • HSV
  • EPGLOTTIS EMERGENCY
  • Unilateral enlargement – indicate malignancy
  • HIV – cervical lymphadenopathy, oroesophageal candidiasis and otitis media
67
Q

is amoxicillin appropriate for tonsillitis

A

NO AS IT MAY BE CUASED BY EBV

CAUSING MACULOPAPULAR RASK