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Maria's Renal Pharm Cards > Thomas 2 > Flashcards

Thomas 2 Flashcards

1
Q

Degaralix is a

A

GnRH antagonist

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2
Q

Leuprolide is a

A

GnRH agonist

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3
Q

Goserelin is a

A

GnRH agonist

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4
Q

Finasteride blocks

A

5-alpha reductase

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5
Q

Flutamide blocks

It (is/is not) a steroid

A

Androgen receptor complex

is not

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6
Q

Cyptroterone blocks

It (is/is not) a steroid

A

Androgen receptor complex

is

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7
Q

Spironolactone blocks

A

Androgen receptor complex

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8
Q

nilutamide blocks

It (is/is not) a steroid

A

Androgen receptor complex

Is not

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9
Q

bicalutamide blocks

It (is/is not) a steroid

A

Androgen receptor complex

Is not

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10
Q

used to treat BPH, but not good for prostate cx

A

finasteride

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11
Q

Indication for thiotepa

A

Bladder cancer, intravesicular

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12
Q

Indication for mitomycin

A

Bladder cancer, intravesicular

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13
Q

Indication for valrubicin

A

Bladder cancer, intravesicular

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14
Q

Indication for Methotrexate

A

Bladder cancer, systemic

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15
Q

Indication for vinblastine

A

Bladder cancer, systemic

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16
Q

Indication for doxorubicin

A

Bladder cancer, systemic

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17
Q

Indication for carboplatin

A

Bladder cancer, systemic

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18
Q

Indication for IL-2

A

renal cell cancer

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19
Q

indication for sunitinib

MOA for sunitinib

A

renal cell carcinoma

inhibits receptor tyrosine kinases (VEGF, PDGF)

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20
Q

Indication for sorafenib

MOA

A

Renal Cell Carcinoma

Inhibits VEGF-Receptor

21
Q

Indication for Bevacizumab

MOA

A

Renal Cell carcinoma

mAb against VEGF

22
Q

Indication for Pazopanib

MOA

A

Renal Cell Carcinoma

Inhibits tyrosine kinase of VEGFR

23
Q

Indication for Aztreonam

A

enterobacter and pseudomonas

resistant to plasmid beta lactamase

24
Q

ok for PCN allergies

A

aztreonam

25
Q

urinayr catheter ass UTI is usu caused by AAA and should be treated with BBB

A

A. enterobacter (G-)

B. aminoglycosides

26
Q

aminoglycosides bind to

A

30S ribosomal subunit

27
Q

major side effects of aminoglycosides (2)

Which is reversible and which is irreversible

A

nephrotox and ototox

nephro - reversible
Ototox - irreversible

28
Q

Fanconi’s can be the result from

A

tetracyclines

29
Q

tetracyclines can produce (3)

A

renal tubular acidosis
azotemia
fanconi’s

30
Q

tetracyclines are excreted by

A

kidneys (except doxy)

31
Q

E. coli is resistant to

A

doxycycline

32
Q

An apparent UTI caused by STD is treated with

A

doxycycline and azythromycin

33
Q

Used for UTI prophylaxis

A

Bactrim

34
Q

How does Bactrim work?

A

Blocks folate synthesis

35
Q

Wierdo quinolones for G (-) only

A

Nalidixic Acid

Cinoxacin

36
Q

How do quinolones work on G-?

A

inhibit DNA gyrase

37
Q

How do quinolones work on G+?

A

Inhibit topoIV

38
Q

used for prophylaxis of chronic UTI. Metabolized to formaldehyde spontaneously at low urine pH

A

Methenamine

39
Q

Effective against G(+) and G(-) E. Coli, but not Proteus, Pseudomonas, Enterobacter, and Klebsiella

A

Nitrofurantion

40
Q

Primary treatment of schistosomes

A

Praziquantel

41
Q

secondary treatment of S. Mansoni

A

Oxamniquine

42
Q

Secondary treatment of S. Haematobium

A

Metrofinate

43
Q

Secondary treatment of S. Japonicum

A

None

44
Q

schistosome found in South America, Africa, Middle east infects Liver, spleen, GI

A

Mansoni

45
Q

schistosome found in Africa, Middle East. Infects Urinary and genital tracts

A

Haemotobium

46
Q

schistosome found in China and Philippines. Infects liver, spleen, GI

A

Japonicum

47
Q

for schistosoma; SE: causes muscular contraction and paralysis

A

Praziquantel

48
Q

for schistosoma; must be activated to dichlorovos, which inhibits Ach

A

metrifonate

for Haematobium

49
Q

For schistosoma; converted to an ester, which dissociates and results in electrophilic reactant alkylates schistosome DNA

A

Oxamniquine

For mansoni

Maria's Renal Pharm Cards (2 decks)

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