Thiopental Soduim Flashcards
1
Q
physical characteristics
A
.Yellowish powder .Bitter taste. Faint smell of garlic Stored in Nitrogen to h prevent reaction with atmospheric CO2 Mixed with 6%angydrius Sodium Bicarbonate to ∆its solubility 509mg and dissolved in distilled H2O to produce 2.5%(25mg/ml) pH of 10.8
2
Q
pH
A
10.8
3
Q
storage of reconstitution
A
48hrs at room temp
>7%potency if stored a 25°c fridge for 5days
kept for 45days if temp is kept at5°C
4
Q
pKa
A
7.6
5
Q
onset
A
3Os but delay may occur with low cardic output
6
Q
effects on CNS
A
progressive depression if the CNS Hypnotic action is potent analgesic effect is poor large doses needed to achieve surgical anaesthesia CMR is reduced dcr in CBF, cerebral blood volume, ICP potent can't convulsant
7
Q
duration
A
5-10min
8
Q
onset
A
30sec
9
Q
CNS effect
A
potent anticonvulsant, hypnotic action is potent, analgesic effect is poor, large doses needed before surgical anaesthesia, cardio respiratory center is depressed, CMR is reduced; decrease CBF, cerebral bld vol. and ICP.
10
Q
duration of action
A
5-10min
11
Q
CVS effect
A
myocardial contractility is depressed, peripheral vasodilatation, arterial pressure is decreased, profound hypotension may occur with hypovolaemia or cardiac DX, reflex tachycardia
