Things to learn

Question 1

Please draw the acid hydrolysis of aspirin like molecyle

Answer 1

process is reversible

Question 2

Please draw the base hydrolysis of an aspirin like molecule

Answer 2

process is irreversible

Question 3

what is the chronic medication service

Answer 3

POW

Question 4

what is the achieving excellence in pharmacutical care

Answer 4

CATS BIRDS

Question 5

what is the mechanism of doxyrubicin damage to the neart

Answer 5

PDECTAAMDF

Question 6

what is the mechanism of doxyrubicin damage to the neart

Answer 6

PDECTAAMDF

Question 7

how do you calculated dose rate of phenytoin

Answer 7

DR = (Vmax x CssAv)/(Km + CssAv)

Question 8

how do you calculate CssAv for phenytoin

Answer 8

Cssav = (KM X DR)/(CssAv-DR)

Question 9

how do you calculate clearance for phenytoin

Answer 9

CL= VMax / Km+CssAv

Question 10

how do you calculate t1/2 for phenytoin

Answer 10

t1/2 =( 0.693 x V/VMax ) x (Km+CssAv)

Question 11

what is the calculation to work out hepatic clearance

Answer 11

CL= Qh x (fu x Clint)/(Qh+fu x Clint)

Question 12

what is the calculation to correct for phenytoin concentration in hypoalbuminaemia

Answer 12

c corected = Cmeasured/(0.9 x albumin/42)+0.1

Question 13

what is the calculation to correct for phenytoin concentration in hypoalbuminaemia and renal failure

Answer 13

c corected = Cmeasured/(0.48 x 0.9 x albumin/42)+0.1

Question 14

what should you do if you have a patient that has low albumin levels but has not been given any phenytoin and you want to give them some?

Answer 14

give normal loading dose

give normal maintenance dose

Question 15

what should you do of you have a patient that has had phenytoin and they want a top up dose

or

if you have a patient is at steady state phenytoin and you want to give them a change in their maintenance dose

Answer 15

do the calculation to correct for low albumin

use the corrected concentrations to adjust the maintenance dose or chose a top up dose

Question 16

what are the SIGN processes for guidelines

Answer 16

Selection of a topic
Guideline development group
Systematic literature review
Formation of recommendations
Consultation and peer review
Presentation and 
Dissemination