Phenytoin Flashcards
1
Q
how much of phenytoin is normal bound to albumin
A
90% bound
10% unbound
2
Q
what can cause low albuminn
A
kidney disease liver disease malnutrition heart failure acute or chronic inflammation
3
Q
what happens to bound phenytoin concentration if albumin falls
A
bound phenytoin concentration falls
as there is less albumin to keep it in the plasma
4
Q
what happens to the phenytoin fraction unbound if albumin falls
A
fraction unbound increases
5
Q
what happens to the unbound concentration of phenytoin if albumin falls
A
doesnt change
this is because the unbound concentration is only affected bu dosing rate and unbound drug clearance which depends on metabolic activity NOT protein binding
6
Q
what happens to the total phenytoin concentration
A
total concentration decreases
